Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211388204> ?p ?o ?g. }
- W3211388204 endingPage "11309" @default.
- W3211388204 startingPage "11300" @default.
- W3211388204 abstract "βII spectrin (β2SP) is encoded by Sptbn1 and is involved in the regulation of various cell functions. β2SP contributes to the formation of the myelin sheath, which may be related to the mechanism of neuropathy caused by demyelination. As one of the main features of cerebral ischemia, demyelination plays a key role in the mechanism of cerebral ischemia injury. Here, we showed that β2SP levels were increased, and this molecule interacted with TET2 after ischemic injury. Furthermore, we found that the level of TET2 was decreased in the nucleus when β2SP was knocked out after oxygen and glucose deprivation (OGD), and the level of 5hmC was reduced in the OGD+β2SP KO group. In contrast, the expression of β2SP did not change in TET2 KO mice. In addition, the 5hmC sequencing results revealed that β2SP can affect the level of 5hmC, the differentially hydroxymethylated region (DhMR) mainly related with the Calcium signalling pathway, cGMP-PKG signalling pathway, Wnt signalling pathway and Hippo signalling pathway. In summary, our results suggest that β2SP could regulate the gene 5hmC by interacted with TET2 and will become a potential therapeutic target for ischemic stroke." @default.
- W3211388204 created "2021-11-22" @default.
- W3211388204 creator A5019928213 @default.
- W3211388204 creator A5055613862 @default.
- W3211388204 creator A5055740842 @default.
- W3211388204 creator A5063143029 @default.
- W3211388204 creator A5072711933 @default.
- W3211388204 creator A5074140059 @default.
- W3211388204 date "2021-11-19" @default.
- W3211388204 modified "2023-09-24" @default.
- W3211388204 title "β2SP/TET2 complex regulates gene 5hmC modification after cerebral ischemia" @default.
- W3211388204 cites W1550784771 @default.
- W3211388204 cites W1633357948 @default.
- W3211388204 cites W1940421961 @default.
- W3211388204 cites W1969118652 @default.
- W3211388204 cites W1978016955 @default.
- W3211388204 cites W1989457196 @default.
- W3211388204 cites W1994983842 @default.
- W3211388204 cites W1996446743 @default.
- W3211388204 cites W1999284955 @default.
- W3211388204 cites W2006414637 @default.
- W3211388204 cites W2023133533 @default.
- W3211388204 cites W2023765801 @default.
- W3211388204 cites W2031684994 @default.
- W3211388204 cites W2035078793 @default.
- W3211388204 cites W2035240306 @default.
- W3211388204 cites W2040909468 @default.
- W3211388204 cites W2042072470 @default.
- W3211388204 cites W2054724790 @default.
- W3211388204 cites W2056671120 @default.
- W3211388204 cites W2066330966 @default.
- W3211388204 cites W2088708165 @default.
- W3211388204 cites W2096805220 @default.
- W3211388204 cites W2098450707 @default.
- W3211388204 cites W2103297688 @default.
- W3211388204 cites W2108234281 @default.
- W3211388204 cites W2108664872 @default.
- W3211388204 cites W2131860315 @default.
- W3211388204 cites W2169227370 @default.
- W3211388204 cites W2170551349 @default.
- W3211388204 cites W2171808845 @default.
- W3211388204 cites W2265652283 @default.
- W3211388204 cites W2277139466 @default.
- W3211388204 cites W2340593234 @default.
- W3211388204 cites W2547904659 @default.
- W3211388204 cites W2552243272 @default.
- W3211388204 cites W2563499390 @default.
- W3211388204 cites W2765565010 @default.
- W3211388204 cites W2792701473 @default.
- W3211388204 cites W2805297208 @default.
- W3211388204 cites W2884962647 @default.
- W3211388204 cites W2885927279 @default.
- W3211388204 cites W2949873165 @default.
- W3211388204 cites W2964088740 @default.
- W3211388204 cites W2969230346 @default.
- W3211388204 cites W3038400879 @default.
- W3211388204 cites W3134618733 @default.
- W3211388204 cites W3211388204 @default.
- W3211388204 cites W4234767205 @default.
- W3211388204 doi "https://doi.org/10.1111/jcmm.17060" @default.
- W3211388204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34799994" @default.
- W3211388204 hasPublicationYear "2021" @default.
- W3211388204 type Work @default.
- W3211388204 sameAs 3211388204 @default.
- W3211388204 citedByCount "3" @default.
- W3211388204 countsByYear W32113882042021 @default.
- W3211388204 countsByYear W32113882042022 @default.
- W3211388204 countsByYear W32113882042023 @default.
- W3211388204 crossrefType "journal-article" @default.
- W3211388204 hasAuthorship W3211388204A5019928213 @default.
- W3211388204 hasAuthorship W3211388204A5055613862 @default.
- W3211388204 hasAuthorship W3211388204A5055740842 @default.
- W3211388204 hasAuthorship W3211388204A5063143029 @default.
- W3211388204 hasAuthorship W3211388204A5072711933 @default.
- W3211388204 hasAuthorship W3211388204A5074140059 @default.
- W3211388204 hasBestOaLocation W32113882041 @default.
- W3211388204 hasConcept C126322002 @default.
- W3211388204 hasConcept C137620995 @default.
- W3211388204 hasConcept C169760540 @default.
- W3211388204 hasConcept C2776925932 @default.
- W3211388204 hasConcept C2778609137 @default.
- W3211388204 hasConcept C2779134260 @default.
- W3211388204 hasConcept C529278444 @default.
- W3211388204 hasConcept C62478195 @default.
- W3211388204 hasConcept C71924100 @default.
- W3211388204 hasConcept C86803240 @default.
- W3211388204 hasConcept C95444343 @default.
- W3211388204 hasConceptScore W3211388204C126322002 @default.
- W3211388204 hasConceptScore W3211388204C137620995 @default.
- W3211388204 hasConceptScore W3211388204C169760540 @default.
- W3211388204 hasConceptScore W3211388204C2776925932 @default.
- W3211388204 hasConceptScore W3211388204C2778609137 @default.
- W3211388204 hasConceptScore W3211388204C2779134260 @default.
- W3211388204 hasConceptScore W3211388204C529278444 @default.
- W3211388204 hasConceptScore W3211388204C62478195 @default.
- W3211388204 hasConceptScore W3211388204C71924100 @default.
- W3211388204 hasConceptScore W3211388204C86803240 @default.
- W3211388204 hasConceptScore W3211388204C95444343 @default.