Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211416732> ?p ?o ?g. }
- W3211416732 endingPage "1768" @default.
- W3211416732 startingPage "1768" @default.
- W3211416732 abstract "Genetic variants in the apolipoprotein E (APOE) gene are associated with lipid metabolism and lipid-related traits in the non-Hispanic population. There have been limited studies regarding the association between the APOE gene and hypercholesterolemia in the Hispanic population; therefore, our aim for this study is to examine the APOE gene's associations with cholesterol level and its related phenotypes. The APOE gene consists of three different alleles, ε2, ε3, and ε4, with ε4 being associated with dementia and cardiovascular diseases. A total of 1,382 subjects were collected from the Texas Alzheimer's Research and Care Consortium (TARCC, N = 1320) and the Initial Study of Longevity and Dementia from the Rio Grande Valley (ISLD-RGV, N = 62). Questionnaires on demographics, medical history, and blood/saliva samples were collected and APOE genotypes were performed. We observed allele frequencies of the APOE ε3 (96.7%), ε4 (22.6%) and ε2 (6.8%) alleles, respectively. Multivariable logistic regression revealed a significant association between the APOE ε4 allele and hypercholesteremia (p = 1.8 × 10-4) in our studied Hispanic population. We prove for the first time, that the APOE ε4 allele increases the risk for hypercholesterol in Hispanics. Further research is needed to confirm and supports our current findings." @default.
- W3211416732 created "2021-11-22" @default.
- W3211416732 creator A5007988448 @default.
- W3211416732 creator A5020317137 @default.
- W3211416732 creator A5020891809 @default.
- W3211416732 creator A5024131833 @default.
- W3211416732 creator A5033304826 @default.
- W3211416732 creator A5043550890 @default.
- W3211416732 creator A5074638724 @default.
- W3211416732 date "2021-11-08" @default.
- W3211416732 modified "2023-10-18" @default.
- W3211416732 title "APOE Gene Associated with Cholesterol-Related Traits in the Hispanic Population" @default.
- W3211416732 cites W171150731 @default.
- W3211416732 cites W1975730400 @default.
- W3211416732 cites W1979170611 @default.
- W3211416732 cites W1979720174 @default.
- W3211416732 cites W1982579882 @default.
- W3211416732 cites W2011012152 @default.
- W3211416732 cites W2012375413 @default.
- W3211416732 cites W2025584280 @default.
- W3211416732 cites W2038243242 @default.
- W3211416732 cites W2039356797 @default.
- W3211416732 cites W2064528916 @default.
- W3211416732 cites W2065259073 @default.
- W3211416732 cites W2070009842 @default.
- W3211416732 cites W2090862351 @default.
- W3211416732 cites W2090896824 @default.
- W3211416732 cites W2094720661 @default.
- W3211416732 cites W2105914660 @default.
- W3211416732 cites W2126718294 @default.
- W3211416732 cites W2134649645 @default.
- W3211416732 cites W2136613607 @default.
- W3211416732 cites W2167712478 @default.
- W3211416732 cites W2182459071 @default.
- W3211416732 cites W2186574084 @default.
- W3211416732 cites W2188938709 @default.
- W3211416732 cites W2189189168 @default.
- W3211416732 cites W2226732401 @default.
- W3211416732 cites W2538539323 @default.
- W3211416732 cites W2560393860 @default.
- W3211416732 cites W2652911668 @default.
- W3211416732 cites W2736527729 @default.
- W3211416732 cites W2810231090 @default.
- W3211416732 cites W2890852480 @default.
- W3211416732 cites W2899868482 @default.
- W3211416732 cites W2900704955 @default.
- W3211416732 cites W2902045127 @default.
- W3211416732 cites W2947920254 @default.
- W3211416732 cites W2952030146 @default.
- W3211416732 cites W2965285787 @default.
- W3211416732 cites W296948053 @default.
- W3211416732 cites W2976113897 @default.
- W3211416732 cites W2979372170 @default.
- W3211416732 cites W2995606438 @default.
- W3211416732 cites W3002761810 @default.
- W3211416732 cites W3028594500 @default.
- W3211416732 cites W3069395596 @default.
- W3211416732 cites W3097786309 @default.
- W3211416732 cites W3192090228 @default.
- W3211416732 cites W48025246 @default.
- W3211416732 doi "https://doi.org/10.3390/genes12111768" @default.
- W3211416732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8619821" @default.
- W3211416732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34828374" @default.
- W3211416732 hasPublicationYear "2021" @default.
- W3211416732 type Work @default.
- W3211416732 sameAs 3211416732 @default.
- W3211416732 citedByCount "4" @default.
- W3211416732 countsByYear W32114167322022 @default.
- W3211416732 countsByYear W32114167322023 @default.
- W3211416732 crossrefType "journal-article" @default.
- W3211416732 hasAuthorship W3211416732A5007988448 @default.
- W3211416732 hasAuthorship W3211416732A5020317137 @default.
- W3211416732 hasAuthorship W3211416732A5020891809 @default.
- W3211416732 hasAuthorship W3211416732A5024131833 @default.
- W3211416732 hasAuthorship W3211416732A5033304826 @default.
- W3211416732 hasAuthorship W3211416732A5043550890 @default.
- W3211416732 hasAuthorship W3211416732A5074638724 @default.
- W3211416732 hasBestOaLocation W32114167321 @default.
- W3211416732 hasConcept C104317684 @default.
- W3211416732 hasConcept C126322002 @default.
- W3211416732 hasConcept C135763542 @default.
- W3211416732 hasConcept C151956035 @default.
- W3211416732 hasConcept C180754005 @default.
- W3211416732 hasConcept C2779134260 @default.
- W3211416732 hasConcept C2779483572 @default.
- W3211416732 hasConcept C2908647359 @default.
- W3211416732 hasConcept C54355233 @default.
- W3211416732 hasConcept C57089818 @default.
- W3211416732 hasConcept C71924100 @default.
- W3211416732 hasConcept C74909509 @default.
- W3211416732 hasConcept C86803240 @default.
- W3211416732 hasConcept C99454951 @default.
- W3211416732 hasConceptScore W3211416732C104317684 @default.
- W3211416732 hasConceptScore W3211416732C126322002 @default.
- W3211416732 hasConceptScore W3211416732C135763542 @default.
- W3211416732 hasConceptScore W3211416732C151956035 @default.
- W3211416732 hasConceptScore W3211416732C180754005 @default.
- W3211416732 hasConceptScore W3211416732C2779134260 @default.