FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211474336> ?p ?o ?g. }

• W3211474336 endingPage "271" @default.
• W3211474336 startingPage "261" @default.
• W3211474336 abstract "Exogenous insulin (INS) is critical for managing diabetes. However, owing to its short in vivo half-life, frequent injection of INS is un-avoidable, which is both painful and inconvenient, compromising the quality of life. Herein, we developed a laser-regulated INS release system (INS-ICG@ER hydrogel) that allowed an on-demand release of INS from the subcutaneous INS reservoir by remote laser control without the frequent injection of INS. The amino acid hydrogel functions as a hydrogel 3D scaffold material, which offers increased subcutaneous stability of drug loaded erythrocytes (ER). This INS-ICG@ER hydrogel would release INS due to the elevated content of reactive oxygen species (ROS), generated by ICG under laser irritation. Conversely, the ROS would be scavenged without the laser irradiation and stopped the release of INS from INS-ICG@ER hydrogel. Furthermore, the release of INS from INS-ICG@ER hydrogel could be regulated by laser irradiation. The INS-ICG@ER hydrogels could control the hyperglycemia within 2 h in diabetic mice and maintained their normal blood glucose level (BGL) for up to 6 days with laser irradiation 30 min prior to meals avoiding the frequent injection of free INS. This delivery system is an effective method that offers a spatiotemporally controlled release of INS to control the glucose level in vivo." @default.
• W3211474336 created "2021-11-22" @default.
• W3211474336 creator A5011688699 @default.
• W3211474336 creator A5024196365 @default.
• W3211474336 creator A5030068163 @default.
• W3211474336 creator A5043196694 @default.
• W3211474336 creator A5052587649 @default.
• W3211474336 creator A5055115466 @default.
• W3211474336 creator A5056248574 @default.
• W3211474336 creator A5056814780 @default.
• W3211474336 creator A5065447668 @default.
• W3211474336 creator A5073904408 @default.
• W3211474336 creator A5080410732 @default.
• W3211474336 creator A5089736597 @default.
• W3211474336 date "2022-01-01" @default.
• W3211474336 modified "2023-09-30" @default.
• W3211474336 title "Erythrocyte-mimicking subcutaneous platform with a laser-controlled treatment against diabetes" @default.
• W3211474336 cites W1915780530 @default.
• W3211474336 cites W1968646728 @default.
• W3211474336 cites W1988717918 @default.
• W3211474336 cites W2014179967 @default.
• W3211474336 cites W2017263072 @default.
• W3211474336 cites W2027684338 @default.
• W3211474336 cites W2031484324 @default.
• W3211474336 cites W2041324668 @default.
• W3211474336 cites W2052396192 @default.
• W3211474336 cites W2052727603 @default.
• W3211474336 cites W2058225286 @default.
• W3211474336 cites W2109895473 @default.
• W3211474336 cites W2501967816 @default.
• W3211474336 cites W2522465404 @default.
• W3211474336 cites W2591577217 @default.
• W3211474336 cites W2635247409 @default.
• W3211474336 cites W2752572266 @default.
• W3211474336 cites W2789472216 @default.
• W3211474336 cites W2791011305 @default.
• W3211474336 cites W2811375219 @default.
• W3211474336 cites W2884672357 @default.
• W3211474336 cites W2904333462 @default.
• W3211474336 cites W2912756832 @default.
• W3211474336 cites W2923457611 @default.
• W3211474336 cites W2961894976 @default.
• W3211474336 cites W2972869264 @default.
• W3211474336 cites W2997302189 @default.
• W3211474336 cites W3005863697 @default.
• W3211474336 cites W3006745536 @default.
• W3211474336 cites W3007025289 @default.
• W3211474336 cites W3012007520 @default.
• W3211474336 cites W3039273793 @default.
• W3211474336 cites W3048866395 @default.
• W3211474336 cites W2055234726 @default.
• W3211474336 doi "https://doi.org/10.1016/j.jconrel.2021.11.021" @default.
• W3211474336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34798153" @default.
• W3211474336 hasPublicationYear "2022" @default.
• W3211474336 type Work @default.
• W3211474336 sameAs 3211474336 @default.
• W3211474336 citedByCount "10" @default.
• W3211474336 countsByYear W32114743362022 @default.
• W3211474336 countsByYear W32114743362023 @default.
• W3211474336 crossrefType "journal-article" @default.
• W3211474336 hasAuthorship W3211474336A5011688699 @default.
• W3211474336 hasAuthorship W3211474336A5024196365 @default.
• W3211474336 hasAuthorship W3211474336A5030068163 @default.
• W3211474336 hasAuthorship W3211474336A5043196694 @default.
• W3211474336 hasAuthorship W3211474336A5052587649 @default.
• W3211474336 hasAuthorship W3211474336A5055115466 @default.
• W3211474336 hasAuthorship W3211474336A5056248574 @default.
• W3211474336 hasAuthorship W3211474336A5056814780 @default.
• W3211474336 hasAuthorship W3211474336A5065447668 @default.
• W3211474336 hasAuthorship W3211474336A5073904408 @default.
• W3211474336 hasAuthorship W3211474336A5080410732 @default.
• W3211474336 hasAuthorship W3211474336A5089736597 @default.
• W3211474336 hasConcept C108586683 @default.
• W3211474336 hasConcept C111337013 @default.
• W3211474336 hasConcept C120665830 @default.
• W3211474336 hasConcept C121332964 @default.
• W3211474336 hasConcept C134018914 @default.
• W3211474336 hasConcept C136229726 @default.
• W3211474336 hasConcept C150903083 @default.
• W3211474336 hasConcept C178790620 @default.
• W3211474336 hasConcept C185544564 @default.
• W3211474336 hasConcept C185592680 @default.
• W3211474336 hasConcept C207001950 @default.
• W3211474336 hasConcept C2776390293 @default.
• W3211474336 hasConcept C2779820397 @default.
• W3211474336 hasConcept C520434653 @default.
• W3211474336 hasConcept C71924100 @default.
• W3211474336 hasConcept C86803240 @default.
• W3211474336 hasConceptScore W3211474336C108586683 @default.
• W3211474336 hasConceptScore W3211474336C111337013 @default.
• W3211474336 hasConceptScore W3211474336C120665830 @default.
• W3211474336 hasConceptScore W3211474336C121332964 @default.
• W3211474336 hasConceptScore W3211474336C134018914 @default.
• W3211474336 hasConceptScore W3211474336C136229726 @default.
• W3211474336 hasConceptScore W3211474336C150903083 @default.
• W3211474336 hasConceptScore W3211474336C178790620 @default.
• W3211474336 hasConceptScore W3211474336C185544564 @default.
• W3211474336 hasConceptScore W3211474336C185592680 @default.

• next