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- W3211486563 endingPage "3096" @default.
- W3211486563 startingPage "3096" @default.
- W3211486563 abstract "In skin, although the extracellular matrix (ECM) is highly developed in dermis and hypodermis, discrete intercellular spaces between cells of the living epidermal layers are also filled with ECM components. Herein, we review knowledge about structure, localization and role of epidermal hyaluronan (HA), a key ECM molecule. HA is a non-sulfated glycosaminoglycan non-covalently bound to proteins or lipids. Components of the basal lamina maintain some segregation between the epidermis and the underlying dermis, and all epidermal HA is locally synthesized and degraded. Functions of HA in keratinocyte proliferation and differentiation are still controversial. However, through interactions with partners, such as the TSG-6 protein, HA is involved in the formation, organization and stabilization of the epidermal ECM. In addition, epidermal HA is involved in the formation of an efficient epidermal barrier made of cornified keratinocytes. In atopic dermatitis (AD) with profuse alterations of the epidermal barrier, HA is produced in larger amounts by keratinocytes than in normal skin. Epidermal HA inside AD lesional skin is located in enlarged intercellular spaces, likely as the result of disease-related modifications of HA metabolism." @default.
- W3211486563 created "2021-11-22" @default.
- W3211486563 creator A5011128677 @default.
- W3211486563 creator A5060741241 @default.
- W3211486563 creator A5090292105 @default.
- W3211486563 date "2021-11-09" @default.
- W3211486563 modified "2023-09-26" @default.
- W3211486563 title "Epidermal Hyaluronan in Barrier Alteration-Related Disease" @default.
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