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- W3211486568 endingPage "170697" @default.
- W3211486568 startingPage "170697" @default.
- W3211486568 abstract "The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are linked to vascular, heart, kidney, and metabolic disorders. Therefore, the apelinergic system has surfaced as a critical therapeutic strategy for cardiovascular diseases (including pulmonary arterial hypertension), kidney disease, insulin resistance, hyponatremia, preeclampsia, and erectile dysfunction. However, apelin peptides are susceptible to rapid degradation through endogenous peptidases, limiting their use as therapeutic tools and translational potential. These proteases include angiotensin converting enzyme 2, neutral endopeptidase, and kallikrein thereby linking the apelin pathway with other peptide systems. In this context, apelin analogs with enhanced proteolytic stability and synthetic ApelinR agonists emerged as promising pharmacological alternatives. In this review, we focus on discussing the putative roles of the apelin pathway in various physiological systems from function to dysfunction, and emphasizing the therapeutic potential of newly generated metabolically stable apelin analogs and non-peptide ApelinR agonists." @default.
- W3211486568 created "2021-11-22" @default.
- W3211486568 creator A5007325812 @default.
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- W3211486568 creator A5016151180 @default.
- W3211486568 creator A5060451577 @default.
- W3211486568 creator A5088962884 @default.
- W3211486568 date "2022-01-01" @default.
- W3211486568 modified "2023-10-18" @default.
- W3211486568 title "Apelin pathway in cardiovascular, kidney, and metabolic diseases: Therapeutic role of apelin analogs and apelin receptor agonists" @default.
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