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- W3211507638 abstract "Statins is widely used in clinical practice as lipid-lowering drugs and has been proven to be effective in the treatment of cardiovascular, endocrine, metabolic syndrome and other diseases. The latest preclinical evidence shows that statins have anti-proliferation, pro-apoptotic, anti-invasion and radiotherapy sensitization effects on tumor cells, suggesting that statins may become a new type of anti-tumor drugs. For a long time, mevalonate pathway has been proved to play a supporting role in the development of tumor cells. As an effective inhibitor of mevalonate pathway, statins have been proved to have a direct auxiliary anti-tumor effect in a large number of studies. In addition, anti-tumor effects of statins through ferroptosis, pyroptosis, autophagy and tumor microenvironment (TME) have also been gradually discovered. However, the specific mechanism of the antitumor effect of statins in the tumor microenvironment has not been clearly elucidated. Herein, we reviewed the antitumor effects of statins in tumor microenvironment, focusing on hypoxia microenvironment, immune microenvironment, metabolic microenvironment, acid microenvironment and mechanical microenvironment." @default.
- W3211507638 created "2021-11-22" @default.
- W3211507638 creator A5003890695 @default.
- W3211507638 creator A5021464011 @default.
- W3211507638 creator A5026501857 @default.
- W3211507638 creator A5029230534 @default.
- W3211507638 date "2021-11-11" @default.
- W3211507638 modified "2023-10-16" @default.
- W3211507638 title "Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins" @default.
- W3211507638 cites W1157613785 @default.
- W3211507638 cites W1493048246 @default.
- W3211507638 cites W1543746024 @default.
- W3211507638 cites W1578283200 @default.
- W3211507638 cites W1864325817 @default.
- W3211507638 cites W1878812720 @default.
- W3211507638 cites W1913823824 @default.
- W3211507638 cites W1964847767 @default.
- W3211507638 cites W1967587727 @default.
- W3211507638 cites W1972825083 @default.
- W3211507638 cites W1976508599 @default.
- W3211507638 cites W1978139448 @default.
- W3211507638 cites W1993238109 @default.
- W3211507638 cites W1995160678 @default.
- W3211507638 cites W1997183854 @default.
- W3211507638 cites W2000475291 @default.
- W3211507638 cites W2002490399 @default.
- W3211507638 cites W2006202974 @default.
- W3211507638 cites W2006833515 @default.
- W3211507638 cites W2011810742 @default.
- W3211507638 cites W2012255417 @default.
- W3211507638 cites W2015970158 @default.
- W3211507638 cites W2021183081 @default.
- W3211507638 cites W2024206845 @default.
- W3211507638 cites W2027364921 @default.
- W3211507638 cites W2030817463 @default.
- W3211507638 cites W2035059839 @default.
- W3211507638 cites W2035898183 @default.
- W3211507638 cites W2041402659 @default.
- W3211507638 cites W2049491375 @default.
- W3211507638 cites W2051682623 @default.
- W3211507638 cites W2053935373 @default.
- W3211507638 cites W2054979979 @default.
- W3211507638 cites W2058102472 @default.
- W3211507638 cites W2066671159 @default.
- W3211507638 cites W2066715772 @default.
- W3211507638 cites W2067541859 @default.
- W3211507638 cites W2068050569 @default.
- W3211507638 cites W2069722998 @default.
- W3211507638 cites W2070454413 @default.
- W3211507638 cites W2071323198 @default.
- W3211507638 cites W2076598575 @default.
- W3211507638 cites W2078893058 @default.
- W3211507638 cites W2082483448 @default.
- W3211507638 cites W2083729029 @default.
- W3211507638 cites W2084708403 @default.
- W3211507638 cites W2087690546 @default.
- W3211507638 cites W2091593426 @default.
- W3211507638 cites W2101375502 @default.
- W3211507638 cites W2109034822 @default.
- W3211507638 cites W2113362613 @default.
- W3211507638 cites W2117064395 @default.
- W3211507638 cites W2117692326 @default.
- W3211507638 cites W2119896120 @default.
- W3211507638 cites W2121215375 @default.
- W3211507638 cites W2123049006 @default.
- W3211507638 cites W2132399579 @default.
- W3211507638 cites W2140226600 @default.
- W3211507638 cites W2140912399 @default.
- W3211507638 cites W2155052327 @default.
- W3211507638 cites W2155162140 @default.
- W3211507638 cites W2159038842 @default.
- W3211507638 cites W2160852038 @default.
- W3211507638 cites W2165752493 @default.
- W3211507638 cites W2165836181 @default.
- W3211507638 cites W217155269 @default.
- W3211507638 cites W2186581015 @default.
- W3211507638 cites W2273626774 @default.
- W3211507638 cites W2337408646 @default.
- W3211507638 cites W2426003472 @default.
- W3211507638 cites W2469450842 @default.
- W3211507638 cites W2469758901 @default.
- W3211507638 cites W2474115604 @default.
- W3211507638 cites W2500192509 @default.
- W3211507638 cites W2507677381 @default.
- W3211507638 cites W2517092932 @default.
- W3211507638 cites W2553600465 @default.
- W3211507638 cites W2588061679 @default.
- W3211507638 cites W2598820457 @default.
- W3211507638 cites W2604077333 @default.
- W3211507638 cites W2615198789 @default.
- W3211507638 cites W2754635129 @default.
- W3211507638 cites W2767322121 @default.
- W3211507638 cites W2776190850 @default.
- W3211507638 cites W2788594479 @default.
- W3211507638 cites W2791059627 @default.
- W3211507638 cites W2792562552 @default.
- W3211507638 cites W2792875602 @default.
- W3211507638 cites W2799374795 @default.
- W3211507638 cites W2800353792 @default.
- W3211507638 cites W2805393256 @default.