Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211522079> ?p ?o ?g. }
- W3211522079 endingPage "3091" @default.
- W3211522079 startingPage "3091" @default.
- W3211522079 abstract "Chronic infections with either hepatitis B or C virus (HBV or HCV) are among the most common risk factors for developing hepatocellular carcinoma (HCC). The hepatocarcinogenic potential of these viruses is mediated through a wide range of mechanisms, including the induction of chronic inflammation and oxidative stress and the deregulation of cellular pathways by viral proteins. Over the last decade, effective anti-viral agents have made sustained viral suppression or cure a feasible treatment objective for most chronic HBV/HCV patients. Given the tumorigenic potential of HBV/HCV, it is no surprise that obtaining sustained viral suppression or eradication proves to be effective in preventing HCC. This review summarizes the mechanisms by which HCV and HBV exert their hepatocarcinogenic activity and describes in detail the efficacy of anti-HBV and anti-HCV therapies in terms of HCC prevention. Although these treatments significantly reduce the risk for HCC in patients with chronic viral hepatitis, this risk is not eliminated. Therefore, we evaluate potential strategies to improve these outcomes further and address some of the remaining controversies." @default.
- W3211522079 created "2021-11-22" @default.
- W3211522079 creator A5000313377 @default.
- W3211522079 creator A5059746700 @default.
- W3211522079 date "2021-11-09" @default.
- W3211522079 modified "2023-10-17" @default.
- W3211522079 title "Treatment for Viral Hepatitis as Secondary Prevention for Hepatocellular Carcinoma" @default.
- W3211522079 cites W1791683862 @default.
- W3211522079 cites W1835730169 @default.
- W3211522079 cites W1897078779 @default.
- W3211522079 cites W1923206005 @default.
- W3211522079 cites W196169070 @default.
- W3211522079 cites W1964491003 @default.
- W3211522079 cites W1965149282 @default.
- W3211522079 cites W1970228462 @default.
- W3211522079 cites W1981285311 @default.
- W3211522079 cites W1982801665 @default.
- W3211522079 cites W1987509611 @default.
- W3211522079 cites W1992706030 @default.
- W3211522079 cites W1996865638 @default.
- W3211522079 cites W1999099454 @default.
- W3211522079 cites W1999292190 @default.
- W3211522079 cites W2002144368 @default.
- W3211522079 cites W2004054613 @default.
- W3211522079 cites W2004456664 @default.
- W3211522079 cites W2005383067 @default.
- W3211522079 cites W2012824806 @default.
- W3211522079 cites W2015070282 @default.
- W3211522079 cites W2015954989 @default.
- W3211522079 cites W2031415426 @default.
- W3211522079 cites W2041927913 @default.
- W3211522079 cites W2048239668 @default.
- W3211522079 cites W2048374493 @default.
- W3211522079 cites W2052217197 @default.
- W3211522079 cites W2054524196 @default.
- W3211522079 cites W2056689537 @default.
- W3211522079 cites W2064394872 @default.
- W3211522079 cites W2072409852 @default.
- W3211522079 cites W2076038974 @default.
- W3211522079 cites W2078197314 @default.
- W3211522079 cites W2085917459 @default.
- W3211522079 cites W2087556175 @default.
- W3211522079 cites W2090738619 @default.
- W3211522079 cites W2093257326 @default.
- W3211522079 cites W2104389844 @default.
- W3211522079 cites W2107414751 @default.
- W3211522079 cites W2109457390 @default.
- W3211522079 cites W2110605071 @default.
- W3211522079 cites W2114785561 @default.
- W3211522079 cites W2120229610 @default.
- W3211522079 cites W2134987468 @default.
- W3211522079 cites W2138424758 @default.
- W3211522079 cites W2160255518 @default.
- W3211522079 cites W2162566260 @default.
- W3211522079 cites W2163083153 @default.
- W3211522079 cites W2163152566 @default.
- W3211522079 cites W2165984116 @default.
- W3211522079 cites W2185218296 @default.
- W3211522079 cites W2225558783 @default.
- W3211522079 cites W2266736818 @default.
- W3211522079 cites W2296479971 @default.
- W3211522079 cites W2297828361 @default.
- W3211522079 cites W2314866596 @default.
- W3211522079 cites W2326928855 @default.
- W3211522079 cites W2331778563 @default.
- W3211522079 cites W2335168204 @default.
- W3211522079 cites W2335913920 @default.
- W3211522079 cites W2467713285 @default.
- W3211522079 cites W2468199489 @default.
- W3211522079 cites W2472585716 @default.
- W3211522079 cites W2480418585 @default.
- W3211522079 cites W2503755744 @default.
- W3211522079 cites W2520879633 @default.
- W3211522079 cites W2524442417 @default.
- W3211522079 cites W2581675750 @default.
- W3211522079 cites W2583713481 @default.
- W3211522079 cites W2586592186 @default.
- W3211522079 cites W2605644052 @default.
- W3211522079 cites W2605785536 @default.
- W3211522079 cites W2606276381 @default.
- W3211522079 cites W2607138146 @default.
- W3211522079 cites W2626176186 @default.
- W3211522079 cites W2751505630 @default.
- W3211522079 cites W2751640563 @default.
- W3211522079 cites W2754300181 @default.
- W3211522079 cites W2760468835 @default.
- W3211522079 cites W2766366395 @default.
- W3211522079 cites W2769934411 @default.
- W3211522079 cites W2772793183 @default.
- W3211522079 cites W2791839818 @default.
- W3211522079 cites W2792767853 @default.
- W3211522079 cites W2793276816 @default.
- W3211522079 cites W2794050916 @default.
- W3211522079 cites W2801167100 @default.
- W3211522079 cites W2801666689 @default.
- W3211522079 cites W2801818807 @default.
- W3211522079 cites W2883468137 @default.
- W3211522079 cites W2888286934 @default.