Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211567434> ?p ?o ?g. }
- W3211567434 endingPage "5616" @default.
- W3211567434 startingPage "5616" @default.
- W3211567434 abstract "Breast cancer is a public health concern and is currently the fifth cause of mortality worldwide. Identification of different biological subtypes is essential for clinical management; therefore, the role of pathologists is essential and useful tools for immunohistochemistry diagnosis are needed. Polypeptide-GalNAc-transferases are emerging novel biomarkers related to cancer behavior and GalNAc-T13, correlated with aggressiveness in some tumors, is an interesting candidate. Few monoclonal antibodies reacting with native proteins, and not affected by fixation and paraffin embedding, have been reported. The aim of this work was to develop a useful monoclonal antibody anti-GalNAc-T13 and to assess its potential significance in breast cancer diagnosis. We evaluated 6 human breast cancer cell lines, 338 primary breast tumors and 48 metastatic lymph nodes and looked for clinical significance correlating GalNAc-T13 expression with patients' clinical features and survival. We found high GalNAc-T13 expression in 43.8% of the cases and observed a significant higher expression in metastatic lymph nodes, correlating with worse overall survival. We hypothesized several possible molecular mechanisms and their implications. We conclude that GalNAc-T13 may be a novel biomarker in breast cancer, useful for routine pathological diagnosis. Elucidation of molecular mechanisms related to aggressiveness should contribute to understand the role of GalNAc-T13 in breast cancer biology." @default.
- W3211567434 created "2021-11-22" @default.
- W3211567434 creator A5000497947 @default.
- W3211567434 creator A5023245642 @default.
- W3211567434 creator A5024361761 @default.
- W3211567434 creator A5029952399 @default.
- W3211567434 creator A5052638398 @default.
- W3211567434 creator A5053480635 @default.
- W3211567434 creator A5076617235 @default.
- W3211567434 creator A5083352233 @default.
- W3211567434 creator A5090545095 @default.
- W3211567434 date "2021-11-10" @default.
- W3211567434 modified "2023-10-01" @default.
- W3211567434 title "Polypeptide-GalNAc-Transferase-13 Shows Prognostic Impact in Breast Cancer" @default.
- W3211567434 cites W1497435151 @default.
- W3211567434 cites W1514408635 @default.
- W3211567434 cites W1519266993 @default.
- W3211567434 cites W1573555338 @default.
- W3211567434 cites W1964572586 @default.
- W3211567434 cites W197316820 @default.
- W3211567434 cites W1996423252 @default.
- W3211567434 cites W2006096506 @default.
- W3211567434 cites W2015510671 @default.
- W3211567434 cites W2034767282 @default.
- W3211567434 cites W2049433187 @default.
- W3211567434 cites W2081507143 @default.
- W3211567434 cites W2103744743 @default.
- W3211567434 cites W2108975373 @default.
- W3211567434 cites W2119911439 @default.
- W3211567434 cites W2124188308 @default.
- W3211567434 cites W2130280698 @default.
- W3211567434 cites W2131378508 @default.
- W3211567434 cites W2134860457 @default.
- W3211567434 cites W2137548222 @default.
- W3211567434 cites W2143866090 @default.
- W3211567434 cites W2146245454 @default.
- W3211567434 cites W2167081623 @default.
- W3211567434 cites W2169035833 @default.
- W3211567434 cites W2302729801 @default.
- W3211567434 cites W2321393409 @default.
- W3211567434 cites W2411521245 @default.
- W3211567434 cites W2427094283 @default.
- W3211567434 cites W2496103983 @default.
- W3211567434 cites W2553012279 @default.
- W3211567434 cites W2554188434 @default.
- W3211567434 cites W2559567017 @default.
- W3211567434 cites W2567286405 @default.
- W3211567434 cites W2756562465 @default.
- W3211567434 cites W2791482956 @default.
- W3211567434 cites W2801200495 @default.
- W3211567434 cites W2803320472 @default.
- W3211567434 cites W2804103434 @default.
- W3211567434 cites W2805666108 @default.
- W3211567434 cites W2898117290 @default.
- W3211567434 cites W2903812167 @default.
- W3211567434 cites W2959437560 @default.
- W3211567434 cites W2962235462 @default.
- W3211567434 cites W2963593504 @default.
- W3211567434 cites W2976003334 @default.
- W3211567434 cites W2978056808 @default.
- W3211567434 cites W2980885964 @default.
- W3211567434 cites W2994990630 @default.
- W3211567434 cites W3008923213 @default.
- W3211567434 cites W3010942522 @default.
- W3211567434 cites W3016649999 @default.
- W3211567434 cites W3016774208 @default.
- W3211567434 cites W3017086979 @default.
- W3211567434 cites W3022878707 @default.
- W3211567434 cites W3090888016 @default.
- W3211567434 cites W3110515602 @default.
- W3211567434 cites W3126143952 @default.
- W3211567434 cites W3128646645 @default.
- W3211567434 cites W3134362176 @default.
- W3211567434 cites W3138996669 @default.
- W3211567434 cites W3140415241 @default.
- W3211567434 cites W3183115455 @default.
- W3211567434 doi "https://doi.org/10.3390/cancers13225616" @default.
- W3211567434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8616257" @default.
- W3211567434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34830771" @default.
- W3211567434 hasPublicationYear "2021" @default.
- W3211567434 type Work @default.
- W3211567434 sameAs 3211567434 @default.
- W3211567434 citedByCount "1" @default.
- W3211567434 countsByYear W32115674342023 @default.
- W3211567434 crossrefType "journal-article" @default.
- W3211567434 hasAuthorship W3211567434A5000497947 @default.
- W3211567434 hasAuthorship W3211567434A5023245642 @default.
- W3211567434 hasAuthorship W3211567434A5024361761 @default.
- W3211567434 hasAuthorship W3211567434A5029952399 @default.
- W3211567434 hasAuthorship W3211567434A5052638398 @default.
- W3211567434 hasAuthorship W3211567434A5053480635 @default.
- W3211567434 hasAuthorship W3211567434A5076617235 @default.
- W3211567434 hasAuthorship W3211567434A5083352233 @default.
- W3211567434 hasAuthorship W3211567434A5090545095 @default.
- W3211567434 hasBestOaLocation W32115674341 @default.
- W3211567434 hasConcept C121608353 @default.
- W3211567434 hasConcept C126322002 @default.
- W3211567434 hasConcept C142724271 @default.