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- W3211642740 abstract "The kidney is a complex organ composed of more than 30 terminally differentiated cell types that all are required to perform its numerous homeostatic functions. Defects in kidney development are a significant cause of chronic kidney disease in children, which can lead to kidney failure that can only be treated by transplant or dialysis. A better understanding of molecular mechanisms that drive kidney development is important for designing strategies to enhance renal repair and regeneration. In this study, we profiled gene expression in the developing mouse kidney at embryonic day 14.5 at single-cell resolution. Consistent with previous studies, clusters with distinct transcriptional signatures clearly identify major compartments and cell types of the developing kidney. Cell cycle activity distinguishes between the primed and self-renewing sub-populations of nephron progenitors, with increased expression of the cell cycle-related genes Birc5, Cdca3, Smc2 and Smc4 in primed nephron progenitors. In addition, augmented expression of cell cycle related genes Birc5, Cks2, Ccnb1, Ccnd1 and Tuba1a/b was detected in immature distal tubules, suggesting cell cycle regulation may be required for early events of nephron patterning and tubular fusion between the distal nephron and collecting duct epithelia." @default.
- W3211642740 created "2021-11-22" @default.
- W3211642740 creator A5003686398 @default.
- W3211642740 creator A5010308904 @default.
- W3211642740 creator A5010346419 @default.
- W3211642740 creator A5034676026 @default.
- W3211642740 creator A5046206804 @default.
- W3211642740 creator A5071186147 @default.
- W3211642740 date "2021-11-17" @default.
- W3211642740 modified "2023-09-27" @default.
- W3211642740 title "Single-cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis" @default.
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