Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211672388> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3211672388 abstract "Linear functions of the site frequency spectrum (SFS) play a major role for understanding and investigating genetic diversity. Estimators of the mutation rate (e.g. based on the total number of segregating sites or average of the pairwise differences) and tests for neutrality (e.g. Tajima's D) are perhaps the most well-known examples. The distribution of linear functions of the SFS is important for constructing confidence intervals for the estimators, and to determine significance thresholds for neutrality tests. These distributions are often approximated using simulation procedures. In this paper we use multivariate phase-type theory to specify, characterize and calculate the distribution of linear functions of the site frequency spectrum. In particular, we show that many of the classical estimators of the mutation rate are distributed according to a discrete phase-type distribution. Neutrality tests, however, are generally not discrete phase-type distributed. For neutrality tests we derive the probability generating function using continuous multivariate phase-type theory, and numerically invert the function to obtain the distribution. A main result is an analytically tractable formula for the probability generating function of the SFS. Software implementation of the phase-type methodology is available in the R package PhaseTypeR, and R code for the reproduction of our results is available as an accompanying vignette." @default.
- W3211672388 created "2021-11-22" @default.
- W3211672388 creator A5011087513 @default.
- W3211672388 creator A5012639888 @default.
- W3211672388 creator A5076669546 @default.
- W3211672388 date "2021-11-16" @default.
- W3211672388 modified "2023-09-23" @default.
- W3211672388 title "Multivariate phase-type theory for the site frequency spectrum" @default.
- W3211672388 cites W1825691109 @default.
- W3211672388 cites W2013753628 @default.
- W3211672388 cites W2034951669 @default.
- W3211672388 cites W2039656278 @default.
- W3211672388 cites W2063302961 @default.
- W3211672388 cites W2074164491 @default.
- W3211672388 cites W2079062761 @default.
- W3211672388 cites W2116382031 @default.
- W3211672388 cites W2157149092 @default.
- W3211672388 cites W2582129956 @default.
- W3211672388 cites W2616761010 @default.
- W3211672388 cites W2787894218 @default.
- W3211672388 cites W2949810288 @default.
- W3211672388 cites W2951492354 @default.
- W3211672388 cites W2962798467 @default.
- W3211672388 cites W2962990988 @default.
- W3211672388 cites W4213279074 @default.
- W3211672388 cites W4250589301 @default.
- W3211672388 doi "https://doi.org/10.1007/s00285-021-01689-w" @default.
- W3211672388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34783900" @default.
- W3211672388 hasPublicationYear "2021" @default.
- W3211672388 type Work @default.
- W3211672388 sameAs 3211672388 @default.
- W3211672388 citedByCount "3" @default.
- W3211672388 countsByYear W32116723882022 @default.
- W3211672388 countsByYear W32116723882023 @default.
- W3211672388 crossrefType "journal-article" @default.
- W3211672388 hasAuthorship W3211672388A5011087513 @default.
- W3211672388 hasAuthorship W3211672388A5012639888 @default.
- W3211672388 hasAuthorship W3211672388A5076669546 @default.
- W3211672388 hasBestOaLocation W32116723882 @default.
- W3211672388 hasConcept C105795698 @default.
- W3211672388 hasConcept C121332964 @default.
- W3211672388 hasConcept C121864883 @default.
- W3211672388 hasConcept C14036430 @default.
- W3211672388 hasConcept C161584116 @default.
- W3211672388 hasConcept C184898388 @default.
- W3211672388 hasConcept C185429906 @default.
- W3211672388 hasConcept C28826006 @default.
- W3211672388 hasConcept C33923547 @default.
- W3211672388 hasConcept C78458016 @default.
- W3211672388 hasConcept C86803240 @default.
- W3211672388 hasConceptScore W3211672388C105795698 @default.
- W3211672388 hasConceptScore W3211672388C121332964 @default.
- W3211672388 hasConceptScore W3211672388C121864883 @default.
- W3211672388 hasConceptScore W3211672388C14036430 @default.
- W3211672388 hasConceptScore W3211672388C161584116 @default.
- W3211672388 hasConceptScore W3211672388C184898388 @default.
- W3211672388 hasConceptScore W3211672388C185429906 @default.
- W3211672388 hasConceptScore W3211672388C28826006 @default.
- W3211672388 hasConceptScore W3211672388C33923547 @default.
- W3211672388 hasConceptScore W3211672388C78458016 @default.
- W3211672388 hasConceptScore W3211672388C86803240 @default.
- W3211672388 hasIssue "6-7" @default.
- W3211672388 hasLocation W32116723881 @default.
- W3211672388 hasLocation W32116723882 @default.
- W3211672388 hasLocation W32116723883 @default.
- W3211672388 hasLocation W32116723884 @default.
- W3211672388 hasOpenAccess W3211672388 @default.
- W3211672388 hasPrimaryLocation W32116723881 @default.
- W3211672388 hasRelatedWork W1980905932 @default.
- W3211672388 hasRelatedWork W1999189895 @default.
- W3211672388 hasRelatedWork W2000103194 @default.
- W3211672388 hasRelatedWork W2033632298 @default.
- W3211672388 hasRelatedWork W2040248213 @default.
- W3211672388 hasRelatedWork W2042341437 @default.
- W3211672388 hasRelatedWork W2085818158 @default.
- W3211672388 hasRelatedWork W2152704622 @default.
- W3211672388 hasRelatedWork W2189585271 @default.
- W3211672388 hasRelatedWork W2117701737 @default.
- W3211672388 hasVolume "83" @default.
- W3211672388 isParatext "false" @default.
- W3211672388 isRetracted "false" @default.
- W3211672388 magId "3211672388" @default.
- W3211672388 workType "article" @default.