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- W3211712238 abstract "786 SLPI, a 12-14 kDa serine protease inhibitor, is genomically amplified in human ovarian carcinoma. GEP, a 68-88 KDa growth factor transcriptionally upregulated in ovarian cancer, is a proliferation and survival factor. In a wound healing model, SLPI has been shown to bind GEP, preventing its degradation into granulins. We hypothesize there is a unique relationship between SLPI and GEP in the local microenvironment that promotes proliferation and survival in ovarian cancer. In human ovarian cancer cell lines, SLPI protein expression ranges from 2-8 ng/ml in OVCAR3 and SKOV3 but is below detection in Hey-A8. Treatment of Hey A8 and OVCAR 3 cells with anti-SLPI antibody significantly decreases cell number (p" @default.
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- W3211712238 date "2005-05-01" @default.
- W3211712238 modified "2023-09-23" @default.
- W3211712238 title "The role of the secretory leukocyte protease inhibitor (SLPI) and granulin epithelin precursor (GEP) axis in ovarian cancer" @default.
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