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- W3211740611 abstract "Methicillin resistant Staphylococcus aureus strains pose a serious treatment problem because of their multi-drug resistance (MDR). In staphylococcal strains, resistance to macrolides, lincosamides, and streptogramin B (MLSB) correlates with resistance to methicillin. The rapid transmission of erm genes responsible for MLSB resistance has strongly limited the clinical application of traditional macrolides such as erythromycin. On the other hand, in the age of increasing insensitivity to antibiotics the idea of implementing a therapy based on older generation drugs brings hope that the spread of antibiotic resistance will be limited. A thorough understanding of the resistance mechanisms contributes to design of antibiotics that avoid bacterial insensitivity. This review highlights the mechanisms of action of macrolides and mechanism of resistance to these antibiotics among Staphylococcus aureus." @default.
- W3211740611 created "2021-11-22" @default.
- W3211740611 creator A5091385653 @default.
- W3211740611 date "2021-11-17" @default.
- W3211740611 modified "2023-10-06" @default.
- W3211740611 title "Mechanisms of Resistance to Macrolide Antibiotics among Staphylococcus aureus" @default.
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- W3211740611 doi "https://doi.org/10.3390/antibiotics10111406" @default.
- W3211740611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8615237" @default.
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- W3211740611 hasPublicationYear "2021" @default.
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