FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211757705> ?p ?o ?g. }

• W3211757705 endingPage "2833" @default.
• W3211757705 startingPage "2833" @default.
• W3211757705 abstract "This study aims to observe the effects of coix seed oil (CSO) on HT-29 cells and investigate its possible regulation mechanism of the PI3K/Akt signaling pathway. Fatty acid analysis showed that coix seed oil mainly contains oleic acid (50.54%), linoleic acid (33.76%), palmitic acid (11.74%), and stearic acid (2.45%). Fourier transform infrared results found that the fatty acid functional groups present in the oil matched well with the vegetable oil band. The results from CCK-8 assays showed that CSO dose-dependently and time-dependently inhibited the viability of HT-29 cells in vitro. CSO inhibited cell viability, with IC50 values of 5.30 mg/mL for HT-29 obtained after 24 h treatment. Morphological changes were observed by apoptotic body/cell nucleus DNA (Hoechst 33258) staining using inverted and fluorescence microscopy. Moreover, flow cytometry analysis was used to evaluate the cell cycle and cell apoptosis. It showed that CSO induced cell apoptosis and cycle arrest in the G2 phase. Quantitative real-time PCR and Western blotting revealed that CSO induced cell apoptosis by downregulating the PI3K/AKT signaling pathway. Additionally, CSO can cause apoptosis in cancer cells by activating caspase-3, up-regulating Bax, and down-regulating Bcl-2. In conclusion, the results revealed that CSO induced G2 arrest and apoptosis of HT-29 cells by regulating the PI3K/AKT signaling pathway." @default.
• W3211757705 created "2021-11-22" @default.
• W3211757705 creator A5003430757 @default.
• W3211757705 creator A5010902410 @default.
• W3211757705 creator A5057501450 @default.
• W3211757705 creator A5058964600 @default.
• W3211757705 creator A5076385060 @default.
• W3211757705 creator A5082156344 @default.
• W3211757705 creator A5083173336 @default.
• W3211757705 date "2021-11-17" @default.
• W3211757705 modified "2023-09-27" @default.
• W3211757705 title "Anti-Cancer Properties of Coix Seed Oil against HT-29 Colon Cells through Regulation of the PI3K/AKT Signaling Pathway" @default.
• W3211757705 cites W1595863417 @default.
• W3211757705 cites W1599097787 @default.
• W3211757705 cites W1970328954 @default.
• W3211757705 cites W1982326703 @default.
• W3211757705 cites W1982703480 @default.
• W3211757705 cites W1992018931 @default.
• W3211757705 cites W1992285977 @default.
• W3211757705 cites W1999259541 @default.
• W3211757705 cites W2011018910 @default.
• W3211757705 cites W2016736873 @default.
• W3211757705 cites W2044075939 @default.
• W3211757705 cites W2067005914 @default.
• W3211757705 cites W2087239364 @default.
• W3211757705 cites W2168650153 @default.
• W3211757705 cites W2274223112 @default.
• W3211757705 cites W2325614832 @default.
• W3211757705 cites W2338908054 @default.
• W3211757705 cites W2491160856 @default.
• W3211757705 cites W2573121869 @default.
• W3211757705 cites W2586511614 @default.
• W3211757705 cites W2597996025 @default.
• W3211757705 cites W2605132700 @default.
• W3211757705 cites W2608763840 @default.
• W3211757705 cites W2735557749 @default.
• W3211757705 cites W2767286542 @default.
• W3211757705 cites W2781414510 @default.
• W3211757705 cites W2792193000 @default.
• W3211757705 cites W2796479190 @default.
• W3211757705 cites W2886108415 @default.
• W3211757705 cites W2892085140 @default.
• W3211757705 cites W2899700163 @default.
• W3211757705 cites W2903194698 @default.
• W3211757705 cites W2936381173 @default.
• W3211757705 cites W2942705597 @default.
• W3211757705 cites W2951071083 @default.
• W3211757705 cites W2970045605 @default.
• W3211757705 cites W2984955289 @default.
• W3211757705 cites W2992058224 @default.
• W3211757705 cites W2998926627 @default.
• W3211757705 cites W3003403795 @default.
• W3211757705 cites W3014989121 @default.
• W3211757705 cites W3017279781 @default.
• W3211757705 cites W3027988553 @default.
• W3211757705 cites W3045114343 @default.
• W3211757705 cites W3047910739 @default.
• W3211757705 cites W3090739618 @default.
• W3211757705 cites W3106869787 @default.
• W3211757705 cites W3108078819 @default.
• W3211757705 cites W3170435083 @default.
• W3211757705 cites W3183251949 @default.
• W3211757705 cites W3195117358 @default.
• W3211757705 cites W4254448823 @default.
• W3211757705 cites W4294214970 @default.
• W3211757705 doi "https://doi.org/10.3390/foods10112833" @default.
• W3211757705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8621869" @default.
• W3211757705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34829119" @default.
• W3211757705 hasPublicationYear "2021" @default.
• W3211757705 type Work @default.
• W3211757705 sameAs 3211757705 @default.
• W3211757705 citedByCount "8" @default.
• W3211757705 countsByYear W32117577052022 @default.
• W3211757705 countsByYear W32117577052023 @default.
• W3211757705 crossrefType "journal-article" @default.
• W3211757705 hasAuthorship W3211757705A5003430757 @default.
• W3211757705 hasAuthorship W3211757705A5010902410 @default.
• W3211757705 hasAuthorship W3211757705A5057501450 @default.
• W3211757705 hasAuthorship W3211757705A5058964600 @default.
• W3211757705 hasAuthorship W3211757705A5076385060 @default.
• W3211757705 hasAuthorship W3211757705A5082156344 @default.
• W3211757705 hasAuthorship W3211757705A5083173336 @default.
• W3211757705 hasBestOaLocation W32117577051 @default.
• W3211757705 hasConcept C185592680 @default.
• W3211757705 hasConcept C190283241 @default.
• W3211757705 hasConcept C29537977 @default.
• W3211757705 hasConcept C53227056 @default.
• W3211757705 hasConcept C55493867 @default.
• W3211757705 hasConcept C62478195 @default.
• W3211757705 hasConcept C75217442 @default.
• W3211757705 hasConcept C86554907 @default.
• W3211757705 hasConcept C86803240 @default.
• W3211757705 hasConcept C95444343 @default.
• W3211757705 hasConceptScore W3211757705C185592680 @default.
• W3211757705 hasConceptScore W3211757705C190283241 @default.
• W3211757705 hasConceptScore W3211757705C29537977 @default.
• W3211757705 hasConceptScore W3211757705C53227056 @default.
• W3211757705 hasConceptScore W3211757705C55493867 @default.

• next