FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211799825> ?p ?o ?g. }

• W3211799825 endingPage "1949" @default.
• W3211799825 startingPage "1949" @default.
• W3211799825 abstract "The current treatment of autoimmune and chronic inflammatory diseases entails systemic immune suppression, which is associated with increased susceptibility to infections. To restore immune tolerance and reduce systemic side effects, a targeted approach using tolerogenic dendritic cells (tolDCs) is being explored. tolDCs are characterized by the expression of CD11c, the major histocompatibility complex (MHC)II and low levels of co-stimulatory molecules CD40 and CD86. In this study, tolDCs were generated using a human-proteoglycan-derived peptide (hPG) and all-trans retinoic acid (RA). RA-tolDCs not only display a tolerogenic phenotype but also can induce an antigen-specific regulatory T cell (Treg) response in vitro. However, further analysis showed that RA-tolDCs make up a heterogeneous population of DCs, with only a small proportion being antigen-associated tolDCs. To increase the homogeneity of this population, 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG)-containing liposomes were used to encapsulate the relevant antigen together with RA. These liposomes greatly enhanced the proportion of antigen-associated tolDCs in culture. In addition, in mice, we showed that the liposomal co-delivery of antigen and RA can be a more targeted approach to induce antigen-specific tolerance compared to the injection of RA-tolDCs, and that these liposomes can stimulate the generation of antigen-specific Tregs. This work highlights the importance of the co-delivery of an antigen and immunomodulator to minimize off-target effects and systemic side effects and provides new insights in the use of RA for antigen-specific immunotherapy for autoimmune and chronic inflammatory diseases." @default.
• W3211799825 created "2021-11-22" @default.
• W3211799825 creator A5041685428 @default.
• W3211799825 creator A5073457405 @default.
• W3211799825 creator A5077869638 @default.
• W3211799825 creator A5078487481 @default.
• W3211799825 creator A5080799523 @default.
• W3211799825 date "2021-11-17" @default.
• W3211799825 modified "2023-10-05" @default.
• W3211799825 title "Retinoic Acid-Containing Liposomes for the Induction of Antigen-Specific Regulatory T Cells as a Treatment for Autoimmune Diseases" @default.
• W3211799825 cites W1519521580 @default.
• W3211799825 cites W1563583575 @default.
• W3211799825 cites W1579942073 @default.
• W3211799825 cites W1966078792 @default.
• W3211799825 cites W1968973375 @default.
• W3211799825 cites W2006704636 @default.
• W3211799825 cites W2010789559 @default.
• W3211799825 cites W2012565034 @default.
• W3211799825 cites W2016847084 @default.
• W3211799825 cites W2033329215 @default.
• W3211799825 cites W2045717244 @default.
• W3211799825 cites W2084185832 @default.
• W3211799825 cites W2096428863 @default.
• W3211799825 cites W2107631420 @default.
• W3211799825 cites W2109420862 @default.
• W3211799825 cites W2110957620 @default.
• W3211799825 cites W2117379708 @default.
• W3211799825 cites W2137670912 @default.
• W3211799825 cites W2144836936 @default.
• W3211799825 cites W2145172700 @default.
• W3211799825 cites W2148226248 @default.
• W3211799825 cites W2170720046 @default.
• W3211799825 cites W2296598106 @default.
• W3211799825 cites W2496406988 @default.
• W3211799825 cites W2558485988 @default.
• W3211799825 cites W2596865928 @default.
• W3211799825 cites W2768720240 @default.
• W3211799825 cites W2794125535 @default.
• W3211799825 cites W2891474673 @default.
• W3211799825 cites W2895796492 @default.
• W3211799825 cites W2967559605 @default.
• W3211799825 cites W2978817010 @default.
• W3211799825 cites W2992082844 @default.
• W3211799825 cites W3025436605 @default.
• W3211799825 cites W3089064012 @default.
• W3211799825 cites W3120567430 @default.
• W3211799825 cites W3121393276 @default.
• W3211799825 cites W3135582782 @default.
• W3211799825 cites W3162823876 @default.
• W3211799825 cites W3184445472 @default.
• W3211799825 doi "https://doi.org/10.3390/pharmaceutics13111949" @default.
• W3211799825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8620283" @default.
• W3211799825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34834364" @default.
• W3211799825 hasPublicationYear "2021" @default.
• W3211799825 type Work @default.
• W3211799825 sameAs 3211799825 @default.
• W3211799825 citedByCount "4" @default.
• W3211799825 countsByYear W32117998252022 @default.
• W3211799825 countsByYear W32117998252023 @default.
• W3211799825 crossrefType "journal-article" @default.
• W3211799825 hasAuthorship W3211799825A5041685428 @default.
• W3211799825 hasAuthorship W3211799825A5073457405 @default.
• W3211799825 hasAuthorship W3211799825A5077869638 @default.
• W3211799825 hasAuthorship W3211799825A5078487481 @default.
• W3211799825 hasAuthorship W3211799825A5080799523 @default.
• W3211799825 hasBestOaLocation W32117998251 @default.
• W3211799825 hasConcept C147483822 @default.
• W3211799825 hasConcept C203014093 @default.
• W3211799825 hasConcept C207936829 @default.
• W3211799825 hasConcept C2776090121 @default.
• W3211799825 hasConcept C2777702733 @default.
• W3211799825 hasConcept C2781101188 @default.
• W3211799825 hasConcept C2908647359 @default.
• W3211799825 hasConcept C71924100 @default.
• W3211799825 hasConcept C8891405 @default.
• W3211799825 hasConcept C99454951 @default.
• W3211799825 hasConceptScore W3211799825C147483822 @default.
• W3211799825 hasConceptScore W3211799825C203014093 @default.
• W3211799825 hasConceptScore W3211799825C207936829 @default.
• W3211799825 hasConceptScore W3211799825C2776090121 @default.
• W3211799825 hasConceptScore W3211799825C2777702733 @default.
• W3211799825 hasConceptScore W3211799825C2781101188 @default.
• W3211799825 hasConceptScore W3211799825C2908647359 @default.
• W3211799825 hasConceptScore W3211799825C71924100 @default.
• W3211799825 hasConceptScore W3211799825C8891405 @default.
• W3211799825 hasConceptScore W3211799825C99454951 @default.
• W3211799825 hasFunder F4320323768 @default.
• W3211799825 hasIssue "11" @default.
• W3211799825 hasLocation W32117998251 @default.
• W3211799825 hasLocation W32117998252 @default.
• W3211799825 hasLocation W32117998253 @default.
• W3211799825 hasLocation W32117998254 @default.
• W3211799825 hasLocation W32117998255 @default.
• W3211799825 hasOpenAccess W3211799825 @default.
• W3211799825 hasPrimaryLocation W32117998251 @default.
• W3211799825 hasRelatedWork W1971483743 @default.
• W3211799825 hasRelatedWork W2031508422 @default.
• W3211799825 hasRelatedWork W2034707118 @default.

• next