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• W3211876735 abstract "Parkinson's disease (PD) is a prevalent neurodegenerative disorder, displaying not only well-known motor deficits but also gastrointestinal dysfunctions. Consistently, it has been increasingly evident that gut microbiota affects the communication between the gut and the brain in PD pathogenesis, known as the microbiota-gut-brain axis. As an approach to re-establishing a normal microbiota community, fecal microbiota transplantation (FMT) has exerted beneficial effects on PD in recent studies. Here, in this study, we established a chronic rotenone-induced PD mouse model to evaluate the protective effects of FMT treatment on PD and to explore the underlying mechanisms, which also proves the involvement of gut microbiota dysbiosis in PD pathogenesis via the microbiota-gut-brain axis.We demonstrated that gut microbiota dysbiosis induced by rotenone administration caused gastrointestinal function impairment and poor behavioral performances in the PD mice. Moreover, 16S RNA sequencing identified the increase of bacterial genera Akkermansia and Desulfovibrio in fecal samples of rotenone-induced mice. By contrast, FMT treatment remarkably restored the gut microbial community, thus ameliorating the gastrointestinal dysfunctions and the motor deficits of the PD mice. Further experiments revealed that FMT administration alleviated intestinal inflammation and barrier destruction, thus reducing the levels of systemic inflammation. Subsequently, FMT treatment attenuated blood-brain barrier (BBB) impairment and suppressed neuroinflammation in the substantia nigra (SN), which further decreased the damage of dopaminergic neurons. Additional mechanistic investigation discovered that FMT treatment reduced lipopolysaccharide (LPS) levels in the colon, the serum, and the SN, thereafter suppressing the TLR4/MyD88/NF-κB signaling pathway and its downstream pro-inflammatory products both in the SN and the colon.Our current study demonstrates that FMT treatment can correct the gut microbiota dysbiosis and ameliorate the rotenone-induced PD mouse model, in which suppression of the inflammation mediated by the LPS-TLR4 signaling pathway both in the gut and the brain possibly plays a significant role. Further, we prove that rotenone-induced microbiota dysbiosis is involved in the genesis of PD via the microbiota-gut-brain axis. Video abstract." @default.
• W3211876735 created "2021-11-22" @default.
• W3211876735 creator A5008147776 @default.
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• W3211876735 creator A5069179290 @default.
• W3211876735 creator A5072881951 @default.
• W3211876735 creator A5077369941 @default.
• W3211876735 creator A5086559201 @default.
• W3211876735 date "2021-11-17" @default.
• W3211876735 modified "2023-10-10" @default.
• W3211876735 title "Fecal microbiota transplantation protects rotenone-induced Parkinson’s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis" @default.
• W3211876735 cites W1563993759 @default.
• W3211876735 cites W1574681462 @default.
• W3211876735 cites W1660608324 @default.
• W3211876735 cites W1869241081 @default.
• W3211876735 cites W1903888485 @default.
• W3211876735 cites W1934236512 @default.
• W3211876735 cites W1969175670 @default.
• W3211876735 cites W1973153021 @default.
• W3211876735 cites W1988940166 @default.
• W3211876735 cites W1989440320 @default.
• W3211876735 cites W2001464444 @default.
• W3211876735 cites W2004123088 @default.
• W3211876735 cites W2012270457 @default.
• W3211876735 cites W2029308328 @default.
• W3211876735 cites W2030108859 @default.
• W3211876735 cites W2030500910 @default.
• W3211876735 cites W2033023829 @default.
• W3211876735 cites W2036863248 @default.
• W3211876735 cites W2048359070 @default.
• W3211876735 cites W2058344677 @default.
• W3211876735 cites W2059341594 @default.
• W3211876735 cites W2079606458 @default.
• W3211876735 cites W2088833470 @default.
• W3211876735 cites W2099448948 @default.
• W3211876735 cites W2106022949 @default.
• W3211876735 cites W2106744168 @default.
• W3211876735 cites W2110300022 @default.
• W3211876735 cites W2126795224 @default.
• W3211876735 cites W2132548846 @default.
• W3211876735 cites W2133293185 @default.
• W3211876735 cites W2133856765 @default.
• W3211876735 cites W2145954079 @default.
• W3211876735 cites W2151350595 @default.
• W3211876735 cites W2152885278 @default.
• W3211876735 cites W2293877091 @default.
• W3211876735 cites W2316524210 @default.
• W3211876735 cites W2508023300 @default.
• W3211876735 cites W2552041992 @default.
• W3211876735 cites W2558041282 @default.
• W3211876735 cites W2575605891 @default.
• W3211876735 cites W2584311212 @default.
• W3211876735 cites W2587959748 @default.
• W3211876735 cites W2589764628 @default.
• W3211876735 cites W2595255900 @default.
• W3211876735 cites W2599986470 @default.
• W3211876735 cites W2607019262 @default.
• W3211876735 cites W2607068511 @default.
• W3211876735 cites W2607879065 @default.
• W3211876735 cites W2608965099 @default.
• W3211876735 cites W2609398719 @default.
• W3211876735 cites W2613763302 @default.
• W3211876735 cites W2616539606 @default.
• W3211876735 cites W2616733389 @default.
• W3211876735 cites W2616818052 @default.
• W3211876735 cites W2734566898 @default.
• W3211876735 cites W2746835184 @default.
• W3211876735 cites W2769248573 @default.
• W3211876735 cites W2782323684 @default.
• W3211876735 cites W2789725922 @default.
• W3211876735 cites W2789728109 @default.
• W3211876735 cites W2790781105 @default.
• W3211876735 cites W2790863554 @default.
• W3211876735 cites W2800577687 @default.
• W3211876735 cites W2801763052 @default.
• W3211876735 cites W2807153072 @default.
• W3211876735 cites W2888863770 @default.
• W3211876735 cites W2889593111 @default.
• W3211876735 cites W2896204288 @default.
• W3211876735 cites W2905177566 @default.
• W3211876735 cites W2905645620 @default.
• W3211876735 cites W2951344089 @default.
• W3211876735 cites W2953625730 @default.
• W3211876735 cites W2953793262 @default.
• W3211876735 cites W2954479056 @default.
• W3211876735 cites W2960949337 @default.
• W3211876735 cites W2965325483 @default.
• W3211876735 cites W2965398438 @default.
• W3211876735 cites W2968691351 @default.
• W3211876735 cites W2980199089 @default.
• W3211876735 cites W2980275875 @default.
• W3211876735 cites W2982993456 @default.
• W3211876735 cites W2989647074 @default.
• W3211876735 cites W3001966824 @default.
• W3211876735 cites W3009775645 @default.
• W3211876735 cites W3011667967 @default.
• W3211876735 cites W3013060838 @default.
• W3211876735 cites W3015095871 @default.
• W3211876735 cites W3016826587 @default.

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