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• W3211931058 abstract "Tissue inhibitors of metalloproteinase (TIMP) family proteins are peptidases involved in extracellular matrix (ECM) degradation. Various diseases are related to TIMPs, and the primary reason is that TIMPs can indirectly regulate remodelling of the ECM and cell signalling by regulating matrix metalloproteinase (MMP) activity. However, the link between TIMPs and glioblastoma (GBM) is unclear.This study aimed to explore the role of TIMP expression and immune infiltration in GBM.Oncomine, GEPIA, OSgbm, LinkedOmics, STRING, GeneMANIA, Enrichr, and TIMER were used to conduct differential expression, prognosis, and immune infiltration analyses of TIMPs in GBM.All members of the TIMP family had significantly higher expression levels in GBM. High TIMP3 expression correlated with better overall survival (OS) and disease-specific survival (DSS) in GBM patients. TIMP4 was associated with a long OS in GBM patients. We found a positive relationship between TIMP3 and TIMP4, identifying gene sets with similar or opposite expression directions to those in GBM patients. TIMPs and associated genes are mainly associated with extracellular matrix organization and involve proteoglycan pathways in cancer. The expression levels of TIMPs in GBM correlate with the infiltration of various immune cells, including CD4+ T cells, macrophages, neutrophils, B cells, CD8+ T cells, and dendritic cells.Our study inspires new ideas for the role of TIMPs in GBM and provides new directions for multiple treatment modalities, including immunotherapy, in GBM." @default.
• W3211931058 created "2021-11-22" @default.
• W3211931058 creator A5015400077 @default.
• W3211931058 creator A5046603897 @default.
• W3211931058 creator A5056859770 @default.
• W3211931058 creator A5071711056 @default.
• W3211931058 date "2021-11-15" @default.
• W3211931058 modified "2023-10-06" @default.
• W3211931058 title "Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma" @default.
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