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- W3211935866 abstract "Estrogen receptor (ER+) breast cancer is the most frequently diagnosed breast cancer subtype. Currently, adjuvant treatment for early stage disease consists of endocrine therapy, with or without chemotherapy and bone-targeted therapy, delivered in a risk-adapted manner. Despite this multimodal approach, a significant proportion of high risk patients will develop incurable distant recurrences. There is an ongoing need to develop new treatment strategies that address the biologic causes of treatment failure and to identify the individual patients who can benefit from such interventions. Here we review the clinical investigation of targeted and novel therapies, including inhibitors of the PI3K-AKT-mTOR pathway, oral selective estrogen receptor degraders (SERDs), and PARP-inhibitors for the treatment of early ER+ breast cancer. Furthermore, we highlight opportunities in biomarker development to help guide the delivery of escalated adjuvant strategies." @default.
- W3211935866 created "2021-11-22" @default.
- W3211935866 creator A5008139209 @default.
- W3211935866 creator A5060911347 @default.
- W3211935866 date "2022-03-01" @default.
- W3211935866 modified "2023-09-27" @default.
- W3211935866 title "Development of novel agents for the treatment of early estrogen receptor positive breast cancer" @default.
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- W3211935866 doi "https://doi.org/10.1016/j.breast.2021.11.007" @default.
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