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• W3211965716 abstract "The severe acute respiratory syndrome coronavirus (SARS-CoV-2) initiated a global viral pandemic since late 2019. Understanding that Coronavirus disease (COVID-19) disproportionately affects men than women results in great challenges. Although there is a growing body of published study on this topic, effective explanations underlying these sex differences and their effects on the infection outcome still remain uncertain. We applied a holistic bioinformatics method to investigate molecular variations of known SARS-CoV-2 interacting human proteins mainly expressed in gonadal tissues (testis and ovary), allowing for the identification of potential genetic targets for this infection. Functional enrichment and interaction network analyses were also performed to better investigate the biological differences between testicular and ovarian responses in the SARS-CoV-2 infection, paying particular attention to genes linked to immune-related pathways, reactions of host cells after intracellular infection, steroid hormone biosynthesis, receptor signaling, and the complement cascade, in order to evaluate their potential association with sexual difference in the likelihood of infection and severity of symptoms. The analysis revealed that within the testis network TMPRSS2, ADAM10, SERPING1, and CCR5 were present, while within the ovary network we found BST2, GATA1, ENPEP, TLR4, TLR7, IRF1, and IRF2. Our findings could provide potential targets for forthcoming experimental investigation related to SARS-CoV-2 treatment." @default.
• W3211965716 created "2021-11-22" @default.
• W3211965716 creator A5016511726 @default.
• W3211965716 creator A5026694842 @default.
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• W3211965716 creator A5053067949 @default.
• W3211965716 creator A5089369408 @default.
• W3211965716 date "2021-11-09" @default.
• W3211965716 modified "2023-09-30" @default.
• W3211965716 title "Candidate genes of SARS-CoV-2 gender susceptibility" @default.
• W3211965716 cites W1481432786 @default.
• W3211965716 cites W1514540900 @default.
• W3211965716 cites W1514902666 @default.
• W3211965716 cites W1557940991 @default.
• W3211965716 cites W1907955033 @default.
• W3211965716 cites W1955394435 @default.
• W3211965716 cites W1959181807 @default.
• W3211965716 cites W1963580683 @default.
• W3211965716 cites W1972039621 @default.
• W3211965716 cites W1974670739 @default.
• W3211965716 cites W1987593639 @default.
• W3211965716 cites W2008280956 @default.
• W3211965716 cites W2010458160 @default.
• W3211965716 cites W2025589527 @default.
• W3211965716 cites W2040717081 @default.
• W3211965716 cites W2043922211 @default.
• W3211965716 cites W2045384882 @default.
• W3211965716 cites W2045407060 @default.
• W3211965716 cites W2045877830 @default.
• W3211965716 cites W2048029176 @default.
• W3211965716 cites W2048356493 @default.
• W3211965716 cites W2051177901 @default.
• W3211965716 cites W2063120378 @default.
• W3211965716 cites W2064871272 @default.
• W3211965716 cites W2073244735 @default.
• W3211965716 cites W2083974181 @default.
• W3211965716 cites W2084951281 @default.
• W3211965716 cites W2091129202 @default.
• W3211965716 cites W2094063221 @default.
• W3211965716 cites W2099907766 @default.
• W3211965716 cites W2099917742 @default.
• W3211965716 cites W2109420700 @default.
• W3211965716 cites W2109982451 @default.
• W3211965716 cites W2113038626 @default.
• W3211965716 cites W2117066664 @default.
• W3211965716 cites W2117342688 @default.
• W3211965716 cites W2129938799 @default.
• W3211965716 cites W2134219545 @default.
• W3211965716 cites W2135024966 @default.
• W3211965716 cites W2159514674 @default.
• W3211965716 cites W2159675211 @default.
• W3211965716 cites W2162198627 @default.
• W3211965716 cites W2165049218 @default.
• W3211965716 cites W2165070219 @default.
• W3211965716 cites W2171030481 @default.
• W3211965716 cites W2244891206 @default.
• W3211965716 cites W2319487210 @default.
• W3211965716 cites W2327610104 @default.
• W3211965716 cites W2331901704 @default.
• W3211965716 cites W2343704133 @default.
• W3211965716 cites W2512736946 @default.
• W3211965716 cites W2518536270 @default.
• W3211965716 cites W2611428787 @default.
• W3211965716 cites W2738656797 @default.
• W3211965716 cites W2762461148 @default.
• W3211965716 cites W2809000676 @default.
• W3211965716 cites W2898658081 @default.
• W3211965716 cites W2943605852 @default.
• W3211965716 cites W2945865759 @default.
• W3211965716 cites W2950336920 @default.
• W3211965716 cites W2953152674 @default.
• W3211965716 cites W3001118548 @default.
• W3211965716 cites W3001897055 @default.
• W3211965716 cites W3007622107 @default.
• W3211965716 cites W3008461878 @default.
• W3211965716 cites W3008827533 @default.
• W3211965716 cites W3009723094 @default.
• W3211965716 cites W3009912996 @default.
• W3211965716 cites W3010441732 @default.
• W3211965716 cites W3010763499 @default.
• W3211965716 cites W3011994656 @default.
• W3211965716 cites W3013034316 @default.
• W3211965716 cites W3015228903 @default.
• W3211965716 cites W3015403775 @default.
• W3211965716 cites W3015489274 @default.
• W3211965716 cites W3016123694 @default.
• W3211965716 cites W3016469463 @default.
• W3211965716 cites W3016965546 @default.
• W3211965716 cites W3017114883 @default.
• W3211965716 cites W3017267674 @default.
• W3211965716 cites W3018310975 @default.
• W3211965716 cites W3018507926 @default.
• W3211965716 cites W3020512604 @default.
• W3211965716 cites W3023339305 @default.
• W3211965716 cites W3023859385 @default.
• W3211965716 cites W3025910635 @default.
• W3211965716 cites W3026232146 @default.
• W3211965716 cites W3033153041 @default.
• W3211965716 cites W3035577122 @default.

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