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- W3211987895 abstract "The development of sexually dimorphic gonads is a unique process that starts with the specification of the bipotential genital ridges and culminates with the development of fully differentiated ovaries and testes in females and males, respectively. Research on sex determination has been mostly focused on the identification of sex determination genes, the majority of which encode for proteins and specifically transcription factors such as SOX9 in the testes and FOXL2 in the ovaries. Our understanding of which factors may be critical for sex determination have benefited from the study of human disorders of sex development (DSD) and animal models, such as the mouse and the goat, as these often replicate the same phenotypes observed in humans when mutations or chromosomic rearrangements arise in protein-coding genes. Despite the advances made so far in explaining the role of key factors such as SRY, SOX9, and FOXL2 and the genes they control, what may regulate these factors upstream is not entirely understood, often resulting in the inability to correctly diagnose DSD patients. The role of non-coding DNA, which represents 98% of the human genome, in sex determination has only recently begun to be fully appreciated. In this review, we summarize the current knowledge on the long-range regulation of 2 important sex determination genes, SOX9 and FOXL2, and discuss the challenges that lie ahead and the many avenues of research yet to be explored in the sex determination field." @default.
- W3211987895 created "2021-11-22" @default.
- W3211987895 creator A5025115870 @default.
- W3211987895 creator A5051320746 @default.
- W3211987895 creator A5057186449 @default.
- W3211987895 date "2021-01-01" @default.
- W3211987895 modified "2023-10-17" @default.
- W3211987895 title "Long-Range Regulation of Key Sex Determination Genes" @default.
- W3211987895 cites W1486895198 @default.
- W3211987895 cites W1498970130 @default.
- W3211987895 cites W1501066624 @default.
- W3211987895 cites W1551209963 @default.
- W3211987895 cites W1574722884 @default.
- W3211987895 cites W1600280267 @default.
- W3211987895 cites W1650548358 @default.
- W3211987895 cites W1844738640 @default.
- W3211987895 cites W1912127524 @default.
- W3211987895 cites W1966308082 @default.
- W3211987895 cites W1968142040 @default.
- W3211987895 cites W1973062929 @default.
- W3211987895 cites W1973202954 @default.
- W3211987895 cites W1973295687 @default.
- W3211987895 cites W1976176009 @default.
- W3211987895 cites W1978798189 @default.
- W3211987895 cites W1980786543 @default.
- W3211987895 cites W1982367532 @default.
- W3211987895 cites W1984220883 @default.
- W3211987895 cites W1984397663 @default.
- W3211987895 cites W1987667706 @default.
- W3211987895 cites W1988749905 @default.
- W3211987895 cites W1991758223 @default.
- W3211987895 cites W1994837394 @default.
- W3211987895 cites W1995827355 @default.
- W3211987895 cites W1995926385 @default.
- W3211987895 cites W2005648147 @default.
- W3211987895 cites W2007969716 @default.
- W3211987895 cites W2013107168 @default.
- W3211987895 cites W2013246689 @default.
- W3211987895 cites W2015489559 @default.
- W3211987895 cites W2016553577 @default.
- W3211987895 cites W2016877854 @default.
- W3211987895 cites W2017134168 @default.
- W3211987895 cites W2017288138 @default.
- W3211987895 cites W2019701459 @default.
- W3211987895 cites W2020705320 @default.
- W3211987895 cites W2021864916 @default.
- W3211987895 cites W2022584463 @default.
- W3211987895 cites W2028493257 @default.
- W3211987895 cites W2030985161 @default.
- W3211987895 cites W2031486396 @default.
- W3211987895 cites W2035169933 @default.
- W3211987895 cites W2037313882 @default.
- W3211987895 cites W2038243028 @default.
- W3211987895 cites W2038316987 @default.
- W3211987895 cites W2040579405 @default.
- W3211987895 cites W2047997227 @default.
- W3211987895 cites W2049424035 @default.
- W3211987895 cites W2052492794 @default.
- W3211987895 cites W2052697305 @default.
- W3211987895 cites W2053492776 @default.
- W3211987895 cites W2053795445 @default.
- W3211987895 cites W2056840798 @default.
- W3211987895 cites W2061221481 @default.
- W3211987895 cites W2061262313 @default.
- W3211987895 cites W2068098232 @default.
- W3211987895 cites W2070021921 @default.
- W3211987895 cites W2071630822 @default.
- W3211987895 cites W2072937904 @default.
- W3211987895 cites W2075598942 @default.
- W3211987895 cites W2077223908 @default.
- W3211987895 cites W2077900057 @default.
- W3211987895 cites W2085140131 @default.
- W3211987895 cites W2085899699 @default.
- W3211987895 cites W2088233275 @default.
- W3211987895 cites W2093241467 @default.
- W3211987895 cites W2097396311 @default.
- W3211987895 cites W2098412813 @default.
- W3211987895 cites W2101046644 @default.
- W3211987895 cites W2104373773 @default.
- W3211987895 cites W2105229868 @default.
- W3211987895 cites W2106235028 @default.
- W3211987895 cites W2106381149 @default.
- W3211987895 cites W2113926943 @default.
- W3211987895 cites W2120311603 @default.
- W3211987895 cites W2120585869 @default.
- W3211987895 cites W2126490946 @default.
- W3211987895 cites W2133013442 @default.
- W3211987895 cites W2133819776 @default.
- W3211987895 cites W2135908131 @default.
- W3211987895 cites W2136552248 @default.
- W3211987895 cites W2139836064 @default.
- W3211987895 cites W2142666322 @default.
- W3211987895 cites W2143338249 @default.
- W3211987895 cites W2143373518 @default.
- W3211987895 cites W2146924318 @default.
- W3211987895 cites W2149945210 @default.
- W3211987895 cites W2150134228 @default.
- W3211987895 cites W2151620623 @default.