Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212079076> ?p ?o ?g. }
- W3212079076 abstract "Therapeutic alternatives to treat metastatic renal cell carcinoma (mRCC) are increasing, and combination therapies, including antiangiogenic agents and tyrosine kinase/mTOR/immune checkpoint inhibitors, are identified as the gold standard driven by the results of recent clinical studies. Nevertheless, the real-world RCC population is very heterogeneous, with categories of patients not represented in the enrolled trial population who may not benefit more from these treatments. The purpose of this expert review is to assess the rationale on which tyrosine kinase alone may still be a viable first-line treatment option for some subgroups of patients with mRCC.The first-line treatment with tyrosine kinase inhibitor monotherapy can still be considered an effective tool for addressing selected mRCCs, as highlighted by the successful outcome in a range of subjects such as favorable-risk patients, the ones suffering from autoimmune diseases, those with pancreatic or lung metastases, or previously undergoing organ transplantation and elderly subjects. Some selected categories of patients may still benefit from monotherapy with TKI, and smart sequential therapies can also be considered instead of a combination strategy. Tyrosine kinase inhibitors can also act as immune modulator agents, boosting the immune response to facilitate and potentiate the therapeutic effectiveness of subsequent immunotherapy." @default.
- W3212079076 created "2021-11-22" @default.
- W3212079076 creator A5006755154 @default.
- W3212079076 creator A5012176145 @default.
- W3212079076 creator A5030595144 @default.
- W3212079076 creator A5034433849 @default.
- W3212079076 creator A5041135391 @default.
- W3212079076 creator A5053179795 @default.
- W3212079076 creator A5059201916 @default.
- W3212079076 creator A5060306893 @default.
- W3212079076 creator A5062532607 @default.
- W3212079076 creator A5064767706 @default.
- W3212079076 creator A5085432815 @default.
- W3212079076 date "2021-11-08" @default.
- W3212079076 modified "2023-10-18" @default.
- W3212079076 title "Combination Therapy in Renal Cell Carcinoma: the Best Choice for Every Patient?" @default.
- W3212079076 cites W1558546536 @default.
- W3212079076 cites W1562104909 @default.
- W3212079076 cites W1603146057 @default.
- W3212079076 cites W1970537251 @default.
- W3212079076 cites W1972492013 @default.
- W3212079076 cites W1976841472 @default.
- W3212079076 cites W2021256410 @default.
- W3212079076 cites W2023952988 @default.
- W3212079076 cites W2024086357 @default.
- W3212079076 cites W2028690273 @default.
- W3212079076 cites W2039123767 @default.
- W3212079076 cites W2053377374 @default.
- W3212079076 cites W2062975829 @default.
- W3212079076 cites W2074048861 @default.
- W3212079076 cites W2078746963 @default.
- W3212079076 cites W2085929845 @default.
- W3212079076 cites W2093675794 @default.
- W3212079076 cites W2099088585 @default.
- W3212079076 cites W2100945326 @default.
- W3212079076 cites W2102813808 @default.
- W3212079076 cites W2105453522 @default.
- W3212079076 cites W2110424712 @default.
- W3212079076 cites W2116626838 @default.
- W3212079076 cites W2116949558 @default.
- W3212079076 cites W2128129838 @default.
- W3212079076 cites W2129411754 @default.
- W3212079076 cites W2129820508 @default.
- W3212079076 cites W2135915203 @default.
- W3212079076 cites W2138600064 @default.
- W3212079076 cites W2146711059 @default.
- W3212079076 cites W2149456801 @default.
- W3212079076 cites W2154673330 @default.
- W3212079076 cites W2160120519 @default.
- W3212079076 cites W2165456770 @default.
- W3212079076 cites W2171364700 @default.
- W3212079076 cites W2185075416 @default.
- W3212079076 cites W2263594271 @default.
- W3212079076 cites W2268557403 @default.
- W3212079076 cites W2285092527 @default.
- W3212079076 cites W2300181798 @default.
- W3212079076 cites W2415950182 @default.
- W3212079076 cites W2511951051 @default.
- W3212079076 cites W2528647848 @default.
- W3212079076 cites W2558408743 @default.
- W3212079076 cites W2560124907 @default.
- W3212079076 cites W2572174216 @default.
- W3212079076 cites W2587048937 @default.
- W3212079076 cites W2593338436 @default.
- W3212079076 cites W2593928562 @default.
- W3212079076 cites W2601055810 @default.
- W3212079076 cites W2607357764 @default.
- W3212079076 cites W2611919322 @default.
- W3212079076 cites W2728903533 @default.
- W3212079076 cites W2755951643 @default.
- W3212079076 cites W2757487320 @default.
- W3212079076 cites W2762531851 @default.
- W3212079076 cites W2765314233 @default.
- W3212079076 cites W2766903152 @default.
- W3212079076 cites W2771697100 @default.
- W3212079076 cites W2782333299 @default.
- W3212079076 cites W2789558376 @default.
- W3212079076 cites W2790729376 @default.
- W3212079076 cites W2792937256 @default.
- W3212079076 cites W2794427449 @default.
- W3212079076 cites W2801774047 @default.
- W3212079076 cites W2810825101 @default.
- W3212079076 cites W2891078672 @default.
- W3212079076 cites W2904346214 @default.
- W3212079076 cites W2908127196 @default.
- W3212079076 cites W2911812451 @default.
- W3212079076 cites W2913745075 @default.
- W3212079076 cites W2914267021 @default.
- W3212079076 cites W2921493122 @default.
- W3212079076 cites W2938409495 @default.
- W3212079076 cites W2939335764 @default.
- W3212079076 cites W2943887705 @default.
- W3212079076 cites W2947020554 @default.
- W3212079076 cites W2947589787 @default.
- W3212079076 cites W2947648853 @default.
- W3212079076 cites W2952564192 @default.
- W3212079076 cites W2967350775 @default.
- W3212079076 cites W2974687396 @default.
- W3212079076 cites W2976621574 @default.
- W3212079076 cites W2977743112 @default.