Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212089739> ?p ?o ?g. }
- W3212089739 endingPage "228" @default.
- W3212089739 startingPage "221" @default.
- W3212089739 abstract "Abstract Objective This study investigated associations of adiposity and adiposity‐related biomarkers with incident type 2 diabetes (T2D) among parous women. Methods Among women in the Diabetes Prevention Program (DPP) who reported a previous live birth, circulating biomarkers (leptin, adiponectin, sex hormone‐binding globulin, and alanine aminotransferase; n = 1,711) were measured at enrollment (average: 12 years post partum). Visceral (VAT) and subcutaneous adipose tissue areas at the L2‐L3 region and the L3‐L4 region were quantified by computed tomography ( n = 477). Overall and stratified (by history of gestational diabetes mellitus [GDM]) adjusted Cox proportional hazards models were fit. Results Alanine aminotransferase, L2‐L3 VAT, and L3‐L4 VAT were positively associated (hazard ratio [HR] for 1‐SD increases: 1.073, p = 0.024; 1.251, p = 0.009; 1.272, p = 0.004, respectively), and adiponectin concentration was inversely associated with T2D (HR 0.762, p < 0.001). Whereas leptin concentration was not associated with T2D overall, in GDM‐stratified models, a 1‐SD higher leptin was positively associated with risk of T2D in women without GDM (HR: 1.126, p = 0.016) and inversely in women with a history of GDM (HR: 0.776, p = 0.013, interaction p = 0.002). Conclusions Among parous women, alanine aminotransferase and VAT are positively associated with incident T2D, whereas adiponectin is inversely associated. Leptin is associated with higher risk of T2D in women with a history of GDM but a lower risk in women without a history of GDM." @default.
- W3212089739 created "2021-11-22" @default.
- W3212089739 creator A5002213341 @default.
- W3212089739 creator A5011389314 @default.
- W3212089739 creator A5013215019 @default.
- W3212089739 creator A5031243886 @default.
- W3212089739 creator A5034893498 @default.
- W3212089739 creator A5046448150 @default.
- W3212089739 creator A5050165878 @default.
- W3212089739 creator A5054794985 @default.
- W3212089739 creator A5068120757 @default.
- W3212089739 creator A5072621544 @default.
- W3212089739 creator A5086940958 @default.
- W3212089739 date "2021-11-18" @default.
- W3212089739 modified "2023-10-15" @default.
- W3212089739 title "Adiposity, related biomarkers, and type 2 diabetes after gestational diabetes: The Diabetes Prevention Program" @default.
- W3212089739 cites W101877409 @default.
- W3212089739 cites W1516421212 @default.
- W3212089739 cites W1858090735 @default.
- W3212089739 cites W1935237410 @default.
- W3212089739 cites W1966608496 @default.
- W3212089739 cites W1974363442 @default.
- W3212089739 cites W1988760852 @default.
- W3212089739 cites W1995336836 @default.
- W3212089739 cites W1998358364 @default.
- W3212089739 cites W2016560465 @default.
- W3212089739 cites W2025846514 @default.
- W3212089739 cites W2028647952 @default.
- W3212089739 cites W2043982697 @default.
- W3212089739 cites W2069080505 @default.
- W3212089739 cites W2085586940 @default.
- W3212089739 cites W2096660073 @default.
- W3212089739 cites W2109955513 @default.
- W3212089739 cites W2120729896 @default.
- W3212089739 cites W2122484262 @default.
- W3212089739 cites W2128124045 @default.
- W3212089739 cites W2136424381 @default.
- W3212089739 cites W2142292538 @default.
- W3212089739 cites W2146220680 @default.
- W3212089739 cites W2148327131 @default.
- W3212089739 cites W2154296945 @default.
- W3212089739 cites W2154860874 @default.
- W3212089739 cites W2155295469 @default.
- W3212089739 cites W2155326729 @default.
- W3212089739 cites W2164118055 @default.
- W3212089739 cites W2166996912 @default.
- W3212089739 cites W2167439606 @default.
- W3212089739 cites W2304233060 @default.
- W3212089739 cites W2324175139 @default.
- W3212089739 cites W2407251855 @default.
- W3212089739 cites W2520432709 @default.
- W3212089739 cites W2598089744 @default.
- W3212089739 cites W2607031541 @default.
- W3212089739 cites W2801718507 @default.
- W3212089739 cites W2896916348 @default.
- W3212089739 cites W2897955576 @default.
- W3212089739 cites W2899900504 @default.
- W3212089739 cites W2979825951 @default.
- W3212089739 cites W3000029241 @default.
- W3212089739 cites W3005310693 @default.
- W3212089739 cites W3011530329 @default.
- W3212089739 cites W4295334800 @default.
- W3212089739 doi "https://doi.org/10.1002/oby.23291" @default.
- W3212089739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34796678" @default.
- W3212089739 hasPublicationYear "2021" @default.
- W3212089739 type Work @default.
- W3212089739 sameAs 3212089739 @default.
- W3212089739 citedByCount "2" @default.
- W3212089739 countsByYear W32120897392022 @default.
- W3212089739 countsByYear W32120897392023 @default.
- W3212089739 crossrefType "journal-article" @default.
- W3212089739 hasAuthorship W3212089739A5002213341 @default.
- W3212089739 hasAuthorship W3212089739A5011389314 @default.
- W3212089739 hasAuthorship W3212089739A5013215019 @default.
- W3212089739 hasAuthorship W3212089739A5031243886 @default.
- W3212089739 hasAuthorship W3212089739A5034893498 @default.
- W3212089739 hasAuthorship W3212089739A5046448150 @default.
- W3212089739 hasAuthorship W3212089739A5050165878 @default.
- W3212089739 hasAuthorship W3212089739A5054794985 @default.
- W3212089739 hasAuthorship W3212089739A5068120757 @default.
- W3212089739 hasAuthorship W3212089739A5072621544 @default.
- W3212089739 hasAuthorship W3212089739A5086940958 @default.
- W3212089739 hasBestOaLocation W32120897391 @default.
- W3212089739 hasConcept C126322002 @default.
- W3212089739 hasConcept C131872663 @default.
- W3212089739 hasConcept C134018914 @default.
- W3212089739 hasConcept C171089720 @default.
- W3212089739 hasConcept C207103383 @default.
- W3212089739 hasConcept C2776782570 @default.
- W3212089739 hasConcept C2777180221 @default.
- W3212089739 hasConcept C2777391703 @default.
- W3212089739 hasConcept C2779234561 @default.
- W3212089739 hasConcept C2779434492 @default.
- W3212089739 hasConcept C2780613262 @default.
- W3212089739 hasConcept C2781179581 @default.
- W3212089739 hasConcept C44249647 @default.
- W3212089739 hasConcept C46973012 @default.
- W3212089739 hasConcept C511355011 @default.