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- W3212097684 endingPage "307" @default.
- W3212097684 startingPage "292" @default.
- W3212097684 abstract "Ligands, mostly binding to proteins to form complexes and catalyze chemical reactions, can serve as drug and probe molecules, as well as sensing elements. DNA nanotechnology can integrate the high editability of DNA nanostructures and the biological activity of ligands into functionalized DNA nanostructures in a manner of controlled ligand stoichiometry, type, and arrangement, which provides significant advantages for targeted therapeutics and diagnostics. As therapeutic agents, multiple- and multivalent-ligands functionalized DNA nanostructures increase ligand-receptor affinity and activate multivalent ligand-receptor interactions, enabling improved regulation of cell signaling and enhanced control of cell behavior. As diagnostic agents, multiple ligands interaction via DNA nanostructures endows DNA nanosensors with high sensitivity and excellent signal transduction capability. Herein, we review the principles and advantages of using DNA nanostructures to manipulate ligands for targeted therapeutics and diagnostics and provide future perspectives." @default.
- W3212097684 created "2021-11-22" @default.
- W3212097684 creator A5019424187 @default.
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- W3212097684 creator A5071526749 @default.
- W3212097684 creator A5076637933 @default.
- W3212097684 creator A5089881939 @default.
- W3212097684 date "2021-12-01" @default.
- W3212097684 modified "2023-10-18" @default.
- W3212097684 title "DNA nanotechnology-facilitated ligand manipulation for targeted therapeutics and diagnostics" @default.
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