Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212100007> ?p ?o ?g. }
- W3212100007 abstract "Urinary malignancies refer to a series of malignant tumors that occur in the urinary system and mainly include kidney, bladder, and prostate cancers. Although local or systemic radiotherapy and chemotherapy, immunotherapy, castration therapy and other methods have been applied to treat these diseases, their high recurrence and metastasis rate remain problems for patients. With in-depth research on the pathogenesis of urinary malignant tumors, this work suggests that regulatory cell death (RCD) plays an important role in their occurrence and development. These RCD pathways are stimulated by various internal and external environmental factors and can induce cell death or permit cell survival under the control of various signal molecules, thereby affecting tumor progression or therapeutic efficacy. Among the previously reported RCD methods, necroptosis, pyroptosis, ferroptosis, and neutrophil extracellular traps (NETs) have attracted research attention. These modes transmit death signals through signal molecules, such as cysteine-aspartic proteases (caspase) family and tumor necrosis factor-α (TNF-α) that have a wide and profound influence on tumor proliferation or death and even change the sensitivity of tumor cells to therapy. This review discussed the effects of necroptosis, pyroptosis, ferroptosis, and NETs on kidney, bladder and prostate cancer and summarized the latest research and achievements in these fields. Future directions and possibility of improving the denouement of urinary system tumors treatment by targeting RCD therapy were also explored." @default.
- W3212100007 created "2021-11-22" @default.
- W3212100007 creator A5000944337 @default.
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- W3212100007 creator A5045685144 @default.
- W3212100007 creator A5058985073 @default.
- W3212100007 creator A5081274798 @default.
- W3212100007 date "2021-11-12" @default.
- W3212100007 modified "2023-10-16" @default.
- W3212100007 title "Regulated Cell Death in Urinary Malignancies" @default.
- W3212100007 cites W1513392008 @default.
- W3212100007 cites W1527997039 @default.
- W3212100007 cites W1535350845 @default.
- W3212100007 cites W1539730987 @default.
- W3212100007 cites W1578844443 @default.
- W3212100007 cites W1589007430 @default.
- W3212100007 cites W1690731028 @default.
- W3212100007 cites W1830737736 @default.
- W3212100007 cites W1970470091 @default.
- W3212100007 cites W1971964548 @default.
- W3212100007 cites W1975617209 @default.
- W3212100007 cites W1977521172 @default.
- W3212100007 cites W1978226882 @default.
- W3212100007 cites W1982525225 @default.
- W3212100007 cites W1985614501 @default.
- W3212100007 cites W1988117658 @default.
- W3212100007 cites W1993613360 @default.
- W3212100007 cites W1997183854 @default.
- W3212100007 cites W1998812648 @default.
- W3212100007 cites W2002490399 @default.
- W3212100007 cites W2005789183 @default.
- W3212100007 cites W2007794772 @default.
- W3212100007 cites W2010412413 @default.
- W3212100007 cites W2014710362 @default.
- W3212100007 cites W2029473544 @default.
- W3212100007 cites W2034432182 @default.
- W3212100007 cites W2034808365 @default.
- W3212100007 cites W2042433863 @default.
- W3212100007 cites W2042577315 @default.
- W3212100007 cites W2043174118 @default.
- W3212100007 cites W2050752663 @default.
- W3212100007 cites W2057632732 @default.
- W3212100007 cites W2062356798 @default.
- W3212100007 cites W2065663086 @default.
- W3212100007 cites W2066406269 @default.
- W3212100007 cites W2069027997 @default.
- W3212100007 cites W2074747472 @default.
- W3212100007 cites W2074811600 @default.
- W3212100007 cites W2077317536 @default.
- W3212100007 cites W2077755076 @default.
- W3212100007 cites W2078254281 @default.
- W3212100007 cites W2084708403 @default.
- W3212100007 cites W2087092800 @default.
- W3212100007 cites W2090234862 @default.
- W3212100007 cites W2091083659 @default.
- W3212100007 cites W2091363184 @default.
- W3212100007 cites W2096580246 @default.
- W3212100007 cites W2099365945 @default.
- W3212100007 cites W2100568503 @default.
- W3212100007 cites W2102144390 @default.
- W3212100007 cites W2103396716 @default.
- W3212100007 cites W2104347367 @default.
- W3212100007 cites W2104934425 @default.
- W3212100007 cites W2107704801 @default.
- W3212100007 cites W2114138419 @default.
- W3212100007 cites W2118217258 @default.
- W3212100007 cites W2118621467 @default.
- W3212100007 cites W2118964113 @default.
- W3212100007 cites W2122368175 @default.
- W3212100007 cites W2124573253 @default.
- W3212100007 cites W2133423829 @default.
- W3212100007 cites W2134354145 @default.
- W3212100007 cites W2135338217 @default.
- W3212100007 cites W2135416318 @default.
- W3212100007 cites W2140765540 @default.
- W3212100007 cites W2140995313 @default.
- W3212100007 cites W2144125109 @default.
- W3212100007 cites W2145729091 @default.
- W3212100007 cites W2155162140 @default.
- W3212100007 cites W2158662692 @default.
- W3212100007 cites W2159679709 @default.
- W3212100007 cites W2161830466 @default.
- W3212100007 cites W2163294546 @default.
- W3212100007 cites W2165072468 @default.
- W3212100007 cites W2165275387 @default.
- W3212100007 cites W2237361742 @default.
- W3212100007 cites W2261153787 @default.
- W3212100007 cites W2272984102 @default.
- W3212100007 cites W2302357444 @default.
- W3212100007 cites W2333014531 @default.
- W3212100007 cites W2340990804 @default.
- W3212100007 cites W2346799309 @default.
- W3212100007 cites W2416712076 @default.
- W3212100007 cites W2418107622 @default.
- W3212100007 cites W2418806051 @default.
- W3212100007 cites W2461756806 @default.
- W3212100007 cites W2466230349 @default.