Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212132416> ?p ?o ?g. }
- W3212132416 endingPage "121290" @default.
- W3212132416 startingPage "121290" @default.
- W3212132416 abstract "Transdermal administration has gained much attention due to the remarkable advantages such as patient compliance, drug escape from first-pass elimination, favorable pharmacokinetic profile and prolonged release properties. However, the major limitation of these systems is the limited skin penetration of the stratum corneum, the skin's most important barrier, which protects the body from the insertion of substances from the environment. Transdermal drug delivery systems are aiming to the disruption of the stratum corneum in order for the active pharmaceutical ingredients to enter successfully the circulation. Therefore, nanoparticles are holding a great promise because they can act as effective penetration enhancers due to their small size and other physicochemical properties that will be analyzed thoroughly in this report. Apart from the investigation of the physicochemical parameters, a comparison between the different types of nanoparticles will be performed. The complexity of skin anatomy and the unclear mechanisms of penetration should be taken into consideration to reach some realistic conclusions regarding the way that the described parameters affect the skin permeability. To the best of the authors knowledge, this is among the few reports on the literature describing the technology of transdermal delivery systems and how this technology affects the biological activity." @default.
- W3212132416 created "2021-11-22" @default.
- W3212132416 creator A5003480577 @default.
- W3212132416 creator A5027706277 @default.
- W3212132416 creator A5031810437 @default.
- W3212132416 creator A5050955529 @default.
- W3212132416 creator A5063216069 @default.
- W3212132416 creator A5083228248 @default.
- W3212132416 date "2022-01-01" @default.
- W3212132416 modified "2023-10-16" @default.
- W3212132416 title "The technology of transdermal delivery nanosystems: from design and development to preclinical studies" @default.
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