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- W3212134308 abstract "BACKGROUND Low anterior resection syndrome has a significant impact on the quality of life in rectal cancer survivors. Previous studies comparing laparoscopic to open rectal resection have neglected bowel function outcomes. OBJECTIVE To assess if there is a difference in the functional outcome between patients undergoing laparoscopic versus open resection for rectal adenocarcinoma. DESIGN Cross-sectional prevalence of low anterior resection syndrome was assessed in a secondary analysis of the multi-center phase 3 randomized clinical trial, Australasian Laparoscopic Cancer of the Rectum Trial (ACTRN12609000663257). SETTING Seven study subsites across New Zealand and Australia. PATIENTS Participants were adults with rectal cancer who underwent anterior resection and had bowel continuity. MAIN OUTCOME MEASURES Postoperative bowel function was evaluated using the validated LARS score and Bowel Function Instrument. RESULTS The Australasian Laparoscopic Cancer of the Rectum Trial randomized 475 patients with T1-T3 rectal adenocarcinoma less than 15cm from the anal verge. 257 participants were eligible for, and invited to, participate in additional follow-up. 163 (63%) completed functional follow-up. Overall cross-sectional prevalence of major LARS was 49% (minor LARS 27%). There were no differences in median overall Bowel Function Instrument score nor LARS score between participants undergoing laparoscopic vs. open surgery (66 vs 67, p = 0.52; 31 vs 27, p = 0.24) at a median follow-up of 69 months. LIMITATIONS The major limitations are a result of conducting a secondary analysis; the likelihood of an insufficient sample size to detect a difference in prevalence between the groups and the possibility of selection bias as a subset of the randomized population was analyzed. CONCLUSIONS Bowel dysfunction affects a majority of rectal cancer patients for a significant time after the operation. In this secondary analysis of a randomized trial, surgical approach does not appear to influence the likelihood or severity of low anterior resection syndrome. See Video Abstract at http://links.lww.com/DCR/B794." @default.
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- W3212134308 date "2021-11-11" @default.
- W3212134308 modified "2023-09-23" @default.
- W3212134308 title "Functional Outcome of Laparoscopic Assisted Resection vs Open Resection of Rectal Cancer: A secondary analysis of the Australasian Laparoscopic Cancer of the Rectum Trial." @default.
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