Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212284025> ?p ?o ?g. }
- W3212284025 abstract "Inhibitors of the renin-angiotensin system (RAS) are widely used to treat hypertension. Using mice harboring fluorescent cell lineage tracers, single-cell RNA-Seq, and long-term inhibition of RAS in both mice and humans, we found that deletion of renin or inhibition of the RAS leads to concentric thickening of the intrarenal arteries and arterioles. This severe disease was caused by the multiclonal expansion and transformation of renin cells from a classical endocrine phenotype to a matrix-secretory phenotype: the cells surrounded the vessel walls and induced the accumulation of adjacent smooth muscle cells and extracellular matrix, resulting in blood flow obstruction, focal ischemia, and fibrosis. Ablation of the renin cells via conditional deletion of β1 integrin prevented arteriolar hypertrophy, indicating that renin cells are responsible for vascular disease. Given these findings, prospective morphological studies in humans are necessary to determine the extent of renal vascular damage caused by the widespread use of inhibitors of the RAS." @default.
- W3212284025 created "2021-11-22" @default.
- W3212284025 creator A5029074504 @default.
- W3212284025 creator A5038920819 @default.
- W3212284025 creator A5042533774 @default.
- W3212284025 creator A5048616489 @default.
- W3212284025 creator A5050574832 @default.
- W3212284025 creator A5077007824 @default.
- W3212284025 creator A5081167551 @default.
- W3212284025 creator A5086331770 @default.
- W3212284025 creator A5088875212 @default.
- W3212284025 creator A5090211586 @default.
- W3212284025 date "2021-12-22" @default.
- W3212284025 modified "2023-10-18" @default.
- W3212284025 title "Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and humans" @default.
- W3212284025 cites W1653658786 @default.
- W3212284025 cites W1965727325 @default.
- W3212284025 cites W1967385085 @default.
- W3212284025 cites W1968344288 @default.
- W3212284025 cites W1980196848 @default.
- W3212284025 cites W2021100840 @default.
- W3212284025 cites W2021220177 @default.
- W3212284025 cites W2081426907 @default.
- W3212284025 cites W2089025918 @default.
- W3212284025 cites W2099735579 @default.
- W3212284025 cites W2100409734 @default.
- W3212284025 cites W2103017472 @default.
- W3212284025 cites W2126690315 @default.
- W3212284025 cites W2131271579 @default.
- W3212284025 cites W2136850043 @default.
- W3212284025 cites W2138862624 @default.
- W3212284025 cites W2147279241 @default.
- W3212284025 cites W2149011410 @default.
- W3212284025 cites W2152433426 @default.
- W3212284025 cites W2158762844 @default.
- W3212284025 cites W2159482845 @default.
- W3212284025 cites W2159675211 @default.
- W3212284025 cites W2189757589 @default.
- W3212284025 cites W2197124664 @default.
- W3212284025 cites W2415845651 @default.
- W3212284025 cites W2419103365 @default.
- W3212284025 cites W2472886804 @default.
- W3212284025 cites W2475261460 @default.
- W3212284025 cites W2581946541 @default.
- W3212284025 cites W2592811885 @default.
- W3212284025 cites W2600678046 @default.
- W3212284025 cites W2607490199 @default.
- W3212284025 cites W2619601420 @default.
- W3212284025 cites W2741267358 @default.
- W3212284025 cites W2888083925 @default.
- W3212284025 cites W2891678790 @default.
- W3212284025 cites W2916020270 @default.
- W3212284025 cites W2928665623 @default.
- W3212284025 cites W2997280954 @default.
- W3212284025 cites W3000556283 @default.
- W3212284025 cites W3004465995 @default.
- W3212284025 cites W3012137315 @default.
- W3212284025 cites W3037306312 @default.
- W3212284025 cites W3039159309 @default.
- W3212284025 cites W3040757307 @default.
- W3212284025 cites W3041541923 @default.
- W3212284025 cites W3080656836 @default.
- W3212284025 cites W3150595609 @default.
- W3212284025 cites W3162066421 @default.
- W3212284025 cites W3164692211 @default.
- W3212284025 cites W4205495813 @default.
- W3212284025 cites W4210702584 @default.
- W3212284025 cites W4294216483 @default.
- W3212284025 doi "https://doi.org/10.1172/jci.insight.154337" @default.
- W3212284025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34762601" @default.
- W3212284025 hasPublicationYear "2021" @default.
- W3212284025 type Work @default.
- W3212284025 sameAs 3212284025 @default.
- W3212284025 citedByCount "12" @default.
- W3212284025 countsByYear W32122840252022 @default.
- W3212284025 countsByYear W32122840252023 @default.
- W3212284025 crossrefType "journal-article" @default.
- W3212284025 hasAuthorship W3212284025A5029074504 @default.
- W3212284025 hasAuthorship W3212284025A5038920819 @default.
- W3212284025 hasAuthorship W3212284025A5042533774 @default.
- W3212284025 hasAuthorship W3212284025A5048616489 @default.
- W3212284025 hasAuthorship W3212284025A5050574832 @default.
- W3212284025 hasAuthorship W3212284025A5077007824 @default.
- W3212284025 hasAuthorship W3212284025A5081167551 @default.
- W3212284025 hasAuthorship W3212284025A5086331770 @default.
- W3212284025 hasAuthorship W3212284025A5088875212 @default.
- W3212284025 hasAuthorship W3212284025A5090211586 @default.
- W3212284025 hasBestOaLocation W32122840251 @default.
- W3212284025 hasConcept C126322002 @default.
- W3212284025 hasConcept C134018914 @default.
- W3212284025 hasConcept C167414201 @default.
- W3212284025 hasConcept C189165786 @default.
- W3212284025 hasConcept C198710026 @default.
- W3212284025 hasConcept C2779395532 @default.
- W3212284025 hasConcept C2780091579 @default.
- W3212284025 hasConcept C2780559512 @default.
- W3212284025 hasConcept C2908929049 @default.
- W3212284025 hasConcept C2992686903 @default.
- W3212284025 hasConcept C71924100 @default.
- W3212284025 hasConcept C84393581 @default.