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- W3212296699 endingPage "70" @default.
- W3212296699 startingPage "63" @default.
- W3212296699 abstract "Colorectal cancer is the third most commonly diagnosed cancer, with rectal cancer accounting for 30% of cases. The current standard of care curative treatment for locally advanced rectal cancer is (chemo)radiotherapy followed by surgery and adjuvant chemotherapy. Although neoadjuvant radiotherapy has reduced the risk of local recurrence to less than 10%, the risk of distant metastasis remained high at 30% affecting patient survival. In addition, there is a recognition that there is heterogeneity in tumor biology and treatment response with good responders potentially suitable for treatment de-escalation. Therefore, new treatment sequencing and regimens were investigated. Here, we reviewed the evidence for current neoadjuvant treatment options in patients with locally advanced rectal adenocarcinoma, and highlight the new challenges in this new treatment landscape." @default.
- W3212296699 created "2021-11-22" @default.
- W3212296699 creator A5001910534 @default.
- W3212296699 creator A5052290457 @default.
- W3212296699 creator A5073942102 @default.
- W3212296699 date "2022-03-01" @default.
- W3212296699 modified "2023-10-18" @default.
- W3212296699 title "Current State of Neoadjuvant Radiotherapy for Rectal Cancer" @default.
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