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- W3212303334 endingPage "1067" @default.
- W3212303334 startingPage "1053" @default.
- W3212303334 abstract "Abstract Older adults with lower education are at greater risk for dementia. It is unclear which brain changes lead to these outcomes. Longitudinal imaging-based measures of brain structure and function were examined in adult individuals (baseline age, 45–86 years; two to five visits per participant over 1–9 years). College degree completion differentiates individual-based and neighborhood-based measures of socioeconomic status and disadvantage. Older adults (~65 years and over) without a college degree exhibit a pattern of declining large-scale functional brain network organization (resting-state system segregation) that is less evident in their college-educated peers. Declining brain system segregation predicts impending changes in dementia severity, measured up to 10 years past the last scan date. The prognostic value of brain network change is independent of Alzheimer’s disease (AD)-related genetic risk ( APOE status), the presence of AD-associated pathology (cerebrospinal fluid phosphorylated tau, cortical amyloid) and cortical thinning. These results demonstrate that the trajectory of an individual’s brain network organization varies in relation to their educational attainment and, more broadly, is a unique indicator of individual brain health during older age." @default.
- W3212303334 created "2021-11-22" @default.
- W3212303334 creator A5036709118 @default.
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- W3212303334 creator A5077323251 @default.
- W3212303334 date "2021-11-11" @default.
- W3212303334 modified "2023-10-14" @default.
- W3212303334 title "Long-term prognosis and educational determinants of brain network decline in older adult individuals" @default.
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