Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212313273> ?p ?o ?g. }
- W3212313273 abstract "Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions." @default.
- W3212313273 created "2021-11-22" @default.
- W3212313273 creator A5006511186 @default.
- W3212313273 creator A5023775087 @default.
- W3212313273 creator A5033786142 @default.
- W3212313273 creator A5062671199 @default.
- W3212313273 creator A5064190738 @default.
- W3212313273 date "2021-11-18" @default.
- W3212313273 modified "2023-10-10" @default.
- W3212313273 title "A somatic proteoglycan controls Notch-directed germ cell fate" @default.
- W3212313273 cites W1491961948 @default.
- W3212313273 cites W1871729829 @default.
- W3212313273 cites W1966909343 @default.
- W3212313273 cites W1967341601 @default.
- W3212313273 cites W1968343429 @default.
- W3212313273 cites W1971060969 @default.
- W3212313273 cites W1972706019 @default.
- W3212313273 cites W1972745320 @default.
- W3212313273 cites W1973046509 @default.
- W3212313273 cites W1974719122 @default.
- W3212313273 cites W1979220616 @default.
- W3212313273 cites W1979826378 @default.
- W3212313273 cites W1982429165 @default.
- W3212313273 cites W1985717957 @default.
- W3212313273 cites W1987140299 @default.
- W3212313273 cites W1989303090 @default.
- W3212313273 cites W1993299801 @default.
- W3212313273 cites W1997801717 @default.
- W3212313273 cites W1998418462 @default.
- W3212313273 cites W2011705026 @default.
- W3212313273 cites W2014516971 @default.
- W3212313273 cites W2021206123 @default.
- W3212313273 cites W2026140964 @default.
- W3212313273 cites W2037103320 @default.
- W3212313273 cites W2050054880 @default.
- W3212313273 cites W2050566213 @default.
- W3212313273 cites W2059911455 @default.
- W3212313273 cites W2060297895 @default.
- W3212313273 cites W2069262666 @default.
- W3212313273 cites W2073207312 @default.
- W3212313273 cites W2075269611 @default.
- W3212313273 cites W2076724997 @default.
- W3212313273 cites W2083425643 @default.
- W3212313273 cites W2087895896 @default.
- W3212313273 cites W2091075863 @default.
- W3212313273 cites W2101900451 @default.
- W3212313273 cites W2104987037 @default.
- W3212313273 cites W2107729039 @default.
- W3212313273 cites W2126998616 @default.
- W3212313273 cites W2128246500 @default.
- W3212313273 cites W2130508298 @default.
- W3212313273 cites W2130523142 @default.
- W3212313273 cites W2134254049 @default.
- W3212313273 cites W2139956822 @default.
- W3212313273 cites W2140723001 @default.
- W3212313273 cites W2144375469 @default.
- W3212313273 cites W2145561024 @default.
- W3212313273 cites W2151170075 @default.
- W3212313273 cites W2159584345 @default.
- W3212313273 cites W2162732723 @default.
- W3212313273 cites W2164221181 @default.
- W3212313273 cites W2168656510 @default.
- W3212313273 cites W2169631447 @default.
- W3212313273 cites W2253541563 @default.
- W3212313273 cites W2373238449 @default.
- W3212313273 cites W2546451980 @default.
- W3212313273 cites W2766206423 @default.
- W3212313273 cites W2800074119 @default.
- W3212313273 cites W2805309350 @default.
- W3212313273 cites W2885646175 @default.
- W3212313273 cites W2891018818 @default.
- W3212313273 cites W2899717451 @default.
- W3212313273 cites W2992563067 @default.
- W3212313273 cites W300474456 @default.
- W3212313273 cites W3005757579 @default.
- W3212313273 cites W3044437722 @default.
- W3212313273 cites W4256266823 @default.
- W3212313273 doi "https://doi.org/10.1038/s41467-021-27039-4" @default.
- W3212313273 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8602670" @default.
- W3212313273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34795288" @default.
- W3212313273 hasPublicationYear "2021" @default.
- W3212313273 type Work @default.
- W3212313273 sameAs 3212313273 @default.
- W3212313273 citedByCount "10" @default.
- W3212313273 countsByYear W32123132732022 @default.
- W3212313273 countsByYear W32123132732023 @default.
- W3212313273 crossrefType "journal-article" @default.
- W3212313273 hasAuthorship W3212313273A5006511186 @default.
- W3212313273 hasAuthorship W3212313273A5023775087 @default.
- W3212313273 hasAuthorship W3212313273A5033786142 @default.
- W3212313273 hasAuthorship W3212313273A5062671199 @default.
- W3212313273 hasAuthorship W3212313273A5064190738 @default.
- W3212313273 hasBestOaLocation W32123132731 @default.
- W3212313273 hasConcept C104317684 @default.
- W3212313273 hasConcept C109825262 @default.
- W3212313273 hasConcept C134305767 @default.
- W3212313273 hasConcept C13514818 @default.
- W3212313273 hasConcept C161879069 @default.
- W3212313273 hasConcept C163952510 @default.
- W3212313273 hasConcept C2778944004 @default.