FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212325991> ?p ?o ?g. }

• W3212325991 abstract "Summary Dogma holds that Toxoplasma gondii persists in neurons because neurons cannot clear intracellular parasites, even with IFN-γ stimulation. As several recent studies questioned this idea, we used primary murine neuronal cultures from wild-type and transgenic mice in combination with IFN-γ stimulation and parental and transgenic parasites to reassess IFN-γ dependent neuronal clearance of intracellular parasites. We found that neurons respond to IFN-γ and that a subset of neurons clear intracellular parasites via immunity regulated GTPases. Whole neuron reconstructions from mice infected with parasites that trigger neuron GFP expression only after full invasion revealed that ∼40% of these T. gondii -invaded neurons no longer harbor parasites. Finally, IFN-γ stimulated human stem cell derived neurons showed a ∼ 50% decrease in parasite infection rate when compared to unstimulated cultures. This work highlights the capability of human and murine neurons to mount cytokine-dependent anti- T. gondii defense mechanisms in vitro and in vivo ." @default.
• W3212325991 created "2021-11-22" @default.
• W3212325991 creator A5003199811 @default.
• W3212325991 creator A5011276041 @default.
• W3212325991 creator A5045965613 @default.
• W3212325991 creator A5087949755 @default.
• W3212325991 date "2021-11-11" @default.
• W3212325991 modified "2023-10-16" @default.
• W3212325991 title "IFN-γ stimulated murine and human neurons mount anti-parasitic defenses against the intracellular parasite<i>Toxoplasma gondii</i>" @default.
• W3212325991 cites W1571840817 @default.
• W3212325991 cites W1848937020 @default.
• W3212325991 cites W1911888926 @default.
• W3212325991 cites W1913184799 @default.
• W3212325991 cites W1915939874 @default.
• W3212325991 cites W1970753345 @default.
• W3212325991 cites W1986003731 @default.
• W3212325991 cites W1989652111 @default.
• W3212325991 cites W1992762970 @default.
• W3212325991 cites W1992771067 @default.
• W3212325991 cites W1993484262 @default.
• W3212325991 cites W1995002251 @default.
• W3212325991 cites W1998047654 @default.
• W3212325991 cites W2007108789 @default.
• W3212325991 cites W2010003461 @default.
• W3212325991 cites W2015293161 @default.
• W3212325991 cites W2019442719 @default.
• W3212325991 cites W2020651266 @default.
• W3212325991 cites W2027073533 @default.
• W3212325991 cites W2028552491 @default.
• W3212325991 cites W2032124268 @default.
• W3212325991 cites W2037012882 @default.
• W3212325991 cites W2039596527 @default.
• W3212325991 cites W2058235794 @default.
• W3212325991 cites W2064069843 @default.
• W3212325991 cites W2074035251 @default.
• W3212325991 cites W2075707505 @default.
• W3212325991 cites W2081187312 @default.
• W3212325991 cites W2083873191 @default.
• W3212325991 cites W2086764655 @default.
• W3212325991 cites W2088793850 @default.
• W3212325991 cites W2091276411 @default.
• W3212325991 cites W2097826747 @default.
• W3212325991 cites W2100868544 @default.
• W3212325991 cites W2104135721 @default.
• W3212325991 cites W2106724288 @default.
• W3212325991 cites W2107277218 @default.
• W3212325991 cites W2112114945 @default.
• W3212325991 cites W2124472169 @default.
• W3212325991 cites W2132909642 @default.
• W3212325991 cites W2136006427 @default.
• W3212325991 cites W2148618509 @default.
• W3212325991 cites W2152234597 @default.
• W3212325991 cites W2156831682 @default.
• W3212325991 cites W2160515243 @default.
• W3212325991 cites W2161340854 @default.
• W3212325991 cites W2162641910 @default.
• W3212325991 cites W2164812139 @default.
• W3212325991 cites W2169057905 @default.
• W3212325991 cites W2169421769 @default.
• W3212325991 cites W2271466588 @default.
• W3212325991 cites W2277975317 @default.
• W3212325991 cites W2517169530 @default.
• W3212325991 cites W2747812326 @default.
• W3212325991 cites W2803272440 @default.
• W3212325991 cites W2889705745 @default.
• W3212325991 cites W2903393353 @default.
• W3212325991 cites W2952370016 @default.
• W3212325991 cites W2990588654 @default.
• W3212325991 cites W2995295768 @default.
• W3212325991 cites W2999987499 @default.
• W3212325991 cites W4313305984 @default.
• W3212325991 doi "https://doi.org/10.1101/2021.11.10.468098" @default.
• W3212325991 hasPublicationYear "2021" @default.
• W3212325991 type Work @default.
• W3212325991 sameAs 3212325991 @default.
• W3212325991 citedByCount "0" @default.
• W3212325991 crossrefType "posted-content" @default.
• W3212325991 hasAuthorship W3212325991A5003199811 @default.
• W3212325991 hasAuthorship W3212325991A5011276041 @default.
• W3212325991 hasAuthorship W3212325991A5045965613 @default.
• W3212325991 hasAuthorship W3212325991A5087949755 @default.
• W3212325991 hasBestOaLocation W32123259911 @default.
• W3212325991 hasConcept C102230213 @default.
• W3212325991 hasConcept C104317684 @default.
• W3212325991 hasConcept C141035611 @default.
• W3212325991 hasConcept C153726182 @default.
• W3212325991 hasConcept C159047783 @default.
• W3212325991 hasConcept C159654299 @default.
• W3212325991 hasConcept C169760540 @default.
• W3212325991 hasConcept C202751555 @default.
• W3212325991 hasConcept C203014093 @default.
• W3212325991 hasConcept C24998067 @default.
• W3212325991 hasConcept C2778128430 @default.
• W3212325991 hasConcept C2778794669 @default.
• W3212325991 hasConcept C54355233 @default.
• W3212325991 hasConcept C79879829 @default.
• W3212325991 hasConcept C86803240 @default.
• W3212325991 hasConcept C95444343 @default.
• W3212325991 hasConceptScore W3212325991C102230213 @default.
• W3212325991 hasConceptScore W3212325991C104317684 @default.

• next