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• W3212364519 endingPage "36510" @default.
• W3212364519 startingPage "36502" @default.
• W3212364519 abstract "Immunoglobulin G (IgG) antibodies are an important class of biotherapeutics that target various diseases, such as cancers, neurodegenerative disorders, and autoimmune diseases, yet rapid discrimination of IgG antibodies remains a great challenge due to heterogeneity, flexibility, and large size. Herein, we demonstrate a simplified multicharge-state collision-induced unfolding (CIU) method for rapid differentiation of four IgG isotypes that differ in terms of the numbers and patterns of disulfide bonds, bypassing tedious single charge-state selection in advance. The results presented herein reveal that gas-phase unfolding behaviors have a strong dependence on charge states outside IgG surfaces; therefore, multicharge-state CIU analysis of IgG subtypes could offer a great opportunity to gain deeper insights into their gas-phase structural differentiation. The full discrimination of IgG antibody isoforms that possess different disulfide bond numbers and even subtle disulfide bonding patterns can be achieved based on their charge-dependent gas-phase unfolding behaviors and root-mean square deviation in CIU difference spectra. Taken together, the incorporation of all charge states observed in a native ion mobility-mass spectrometry (IM-MS) experiment to CIU analysis could make this strategy sensitive to more subtle structural discrepancies, facilitating the rapid discrimination and evaluation of innovative structurally similar biotherapeutic candidates with unexplored functions." @default.
• W3212364519 created "2021-11-22" @default.
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• W3212364519 date "2021-01-01" @default.
• W3212364519 modified "2023-09-22" @default.
• W3212364519 title "Rapid structural discrimination of IgG antibodies by multicharge-state collision-induced unfolding" @default.
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• W3212364519 doi "https://doi.org/10.1039/d1ra06486j" @default.
• W3212364519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35494361" @default.
• W3212364519 hasPublicationYear "2021" @default.
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