Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212367088> ?p ?o ?g. }
- W3212367088 abstract "Perinatal white matter injury (WMI) is the most common brain injury in premature infants and can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically accompanied by inflammation and hypoxic-ischemic events. Such perinatal insults negatively impact maturation of oligodendrocytes (OLs) and cause myelination failure. At present, no treatment options are clinically available to prevent or cure WMI. Given that arrested OL maturation plays a central role in the etiology of perinatal WMI, an increased interest has emerged regarding the functional restoration of these cells as potential therapeutic strategy. Cell transplantation and promoting endogenous oligodendrocyte function are two potential options to address this major unmet need. In this review, we highlight the underlying pathophysiology of WMI with a specific focus on OL biology and their implication for the development of new therapeutic targets." @default.
- W3212367088 created "2021-11-22" @default.
- W3212367088 creator A5000167242 @default.
- W3212367088 creator A5034118336 @default.
- W3212367088 date "2021-11-04" @default.
- W3212367088 modified "2023-10-15" @default.
- W3212367088 title "Oligodendrocyte Development and Implication in Perinatal White Matter Injury" @default.
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