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• W3212391143 abstract "Arterioles in the peripheral microcirculation regulate blood flow to and within tissues and organs, control capillary blood pressure and microvascular fluid exchange, govern peripheral vascular resistance, and contribute to the regulation of blood pressure. These important microvessels display pressure-dependent myogenic tone, the steady state level of contractile activity of vascular smooth muscle cells (VSMCs) that sets resting arteriolar internal diameter such that arterioles can both dilate and constrict to meet the blood flow and pressure needs of the tissues and organs that they perfuse. This perspective will focus on the Ca2+-dependent ion channels in the plasma and endoplasmic reticulum membranes of arteriolar VSMCs and endothelial cells (ECs) that regulate arteriolar tone. In VSMCs, Ca2+-dependent negative feedback regulation of myogenic tone is mediated by Ca2+-activated K+ (BKCa) channels and also Ca2+-dependent inactivation of voltage-gated Ca2+ channels (VGCC). Transient receptor potential subfamily M, member 4 channels (TRPM4); Ca2+-activated Cl- channels (CaCCs; TMEM16A/ANO1), Ca2+-dependent inhibition of voltage-gated K+ (KV) and ATP-sensitive K+ (KATP) channels; and Ca2+-induced-Ca2+ release through inositol 1,4,5-trisphosphate receptors (IP3Rs) participate in Ca2+-dependent positive-feedback regulation of myogenic tone. Calcium release from VSMC ryanodine receptors (RyRs) provide negative-feedback through Ca2+-spark-mediated control of BKCa channel activity, or positive-feedback regulation in cooperation with IP3Rs or CaCCs. In some arterioles, VSMC RyRs are silent. In ECs, transient receptor potential vanilloid subfamily, member 4 (TRPV4) channels produce Ca2+ sparklets that activate IP3Rs and intermediate and small conductance Ca2+ activated K+ (IKCa and sKCa) channels causing membrane hyperpolarization that is conducted to overlying VSMCs producing endothelium-dependent hyperpolarization and vasodilation. Endothelial IP3Rs produce Ca2+ pulsars, Ca2+ wavelets, Ca2+ waves and increased global Ca2+ levels activating EC sKCa and IKCa channels and causing Ca2+-dependent production of endothelial vasodilator autacoids such as NO, prostaglandin I2 and epoxides of arachidonic acid that mediate negative-feedback regulation of myogenic tone. Thus, Ca2+-dependent ion channels importantly contribute to many aspects of the regulation of myogenic tone in arterioles in the microcirculation." @default.
• W3212391143 created "2021-11-22" @default.
• W3212391143 creator A5088536388 @default.
• W3212391143 date "2021-11-08" @default.
• W3212391143 modified "2023-10-17" @default.
• W3212391143 title "Calcium-Dependent Ion Channels and the Regulation of Arteriolar Myogenic Tone" @default.
• W3212391143 cites W1162818412 @default.
• W3212391143 cites W1487735792 @default.
• W3212391143 cites W1488266902 @default.
• W3212391143 cites W1488442157 @default.
• W3212391143 cites W1489379070 @default.
• W3212391143 cites W1490915066 @default.
• W3212391143 cites W1505906325 @default.
• W3212391143 cites W1507386113 @default.
• W3212391143 cites W1518621098 @default.
• W3212391143 cites W1528316102 @default.
• W3212391143 cites W1547730299 @default.
• W3212391143 cites W1550564549 @default.
• W3212391143 cites W1575129867 @default.
• W3212391143 cites W1599415631 @default.
• W3212391143 cites W1607460945 @default.
• W3212391143 cites W1771949227 @default.
• W3212391143 cites W1780476192 @default.
• W3212391143 cites W1818338329 @default.
• W3212391143 cites W1834643162 @default.
• W3212391143 cites W1855148143 @default.
• W3212391143 cites W187771043 @default.
• W3212391143 cites W1964567018 @default.
• W3212391143 cites W1965021019 @default.
• W3212391143 cites W1965964492 @default.
• W3212391143 cites W1966329284 @default.
• W3212391143 cites W1967042692 @default.
• W3212391143 cites W1972402288 @default.
• W3212391143 cites W1972772651 @default.
• W3212391143 cites W1977378747 @default.
• W3212391143 cites W1979709326 @default.
• W3212391143 cites W1981091737 @default.
• W3212391143 cites W1981387606 @default.
• W3212391143 cites W1981511382 @default.
• W3212391143 cites W1982320423 @default.
• W3212391143 cites W1985332887 @default.
• W3212391143 cites W1987211770 @default.
• W3212391143 cites W1990314841 @default.
• W3212391143 cites W1991353211 @default.
• W3212391143 cites W1994931711 @default.
• W3212391143 cites W1996579798 @default.
• W3212391143 cites W1997076138 @default.
• W3212391143 cites W1998393115 @default.
• W3212391143 cites W1998719957 @default.
• W3212391143 cites W1999374220 @default.
• W3212391143 cites W1999581470 @default.
• W3212391143 cites W1999935771 @default.
• W3212391143 cites W2000078310 @default.
• W3212391143 cites W2001647794 @default.
• W3212391143 cites W2002287591 @default.
• W3212391143 cites W2002424567 @default.
• W3212391143 cites W2003272398 @default.
• W3212391143 cites W2003716397 @default.
• W3212391143 cites W2005238005 @default.
• W3212391143 cites W2005325543 @default.
• W3212391143 cites W2007781466 @default.
• W3212391143 cites W2009997286 @default.
• W3212391143 cites W2011028126 @default.
• W3212391143 cites W2011403078 @default.
• W3212391143 cites W2012012271 @default.
• W3212391143 cites W2012812713 @default.
• W3212391143 cites W2012863655 @default.
• W3212391143 cites W2014264924 @default.
• W3212391143 cites W2016065780 @default.
• W3212391143 cites W2018480694 @default.
• W3212391143 cites W2019345683 @default.
• W3212391143 cites W2020477012 @default.
• W3212391143 cites W2021630348 @default.
• W3212391143 cites W2024103448 @default.
• W3212391143 cites W2025644518 @default.
• W3212391143 cites W2026585864 @default.
• W3212391143 cites W2027375644 @default.
• W3212391143 cites W2028175193 @default.
• W3212391143 cites W2028269275 @default.
• W3212391143 cites W2029489419 @default.
• W3212391143 cites W2031446260 @default.
• W3212391143 cites W2032019404 @default.
• W3212391143 cites W2034182021 @default.
• W3212391143 cites W2034824212 @default.
• W3212391143 cites W2036082842 @default.
• W3212391143 cites W2037924100 @default.
• W3212391143 cites W2038256300 @default.
• W3212391143 cites W2039694740 @default.
• W3212391143 cites W2040668875 @default.
• W3212391143 cites W2042735691 @default.
• W3212391143 cites W2043288449 @default.
• W3212391143 cites W2043725855 @default.
• W3212391143 cites W2044055102 @default.
• W3212391143 cites W2044246994 @default.
• W3212391143 cites W2046475919 @default.
• W3212391143 cites W2046764126 @default.
• W3212391143 cites W2048492290 @default.
• W3212391143 cites W2049787944 @default.
• W3212391143 cites W2050256938 @default.
• W3212391143 cites W2050402505 @default.

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