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- W3212414245 abstract "Plants used in traditional medicine are potential sources of new analgesic and antiinflammatory drugs, and those belonging to the Solanum genus are not exceptions. Solanum (L) is the largest genus within the Solanaceae family and one of the largest among the angiosperms. Extracts (mostly aqueous and ethanolic extracts) from aerial parts and roots of several Solanum spp. were shown to exhibit antinociceptive and/or antiinflammatory activity in rodent assays. The pharmacodynamic activities of Solanum plant extracts suggest that they are likely to fit into the class of nonsteroidal antiinflammatory drug-like analgesics. So far, however, direct evidence on their inhibitory effects on the cyclooxygenase-mediated synthesis of prostaglandins is missing. Flavonol glycosides and hydroxycinnamates are among the most abundant compounds found in analgesic extracts of Solanum spp. Quercetin, rutin, and hydroxycinnamates possess analgesic and antiinflammatory properties in rodent assays as well. Extracts of Solanum spp. also showed antioxidant and liver-protective effects against different hepatotoxins including acetaminophen. Overall, available evidence seems to support the traditional use of Solanum plant extracts to relieve moderate pain. Phytotherapeutic formulations of Solanum extracts alone or combining them with acetaminophen are promising new effective and safer medications for moderate pain relief." @default.
- W3212414245 created "2021-11-22" @default.
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- W3212414245 date "2022-01-01" @default.
- W3212414245 modified "2023-09-23" @default.
- W3212414245 title "Analgesic properties of plants from the genus Solanum L. (Solanaceae)" @default.
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- W3212414245 doi "https://doi.org/10.1016/b978-0-12-820237-1.00039-9" @default.
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