FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212419102> ?p ?o ?g. }

• W3212419102 endingPage "1470" @default.
• W3212419102 startingPage "1461" @default.
• W3212419102 abstract "Background and Aims Wilson’s disease (WD) is a genetic disease with systemic accumulation of copper that leads to symptoms from the liver and brain. However, the underlying defects in copper transport kinetics are only partly understood. We sought to quantify hepatic copper turnover in patients with WD compared with heterozygote and control subjects using PET with copper-64 (64Cu) as a tracer. Furthermore, we assessed the diagnostic potential of the method. Approach and Results Nine patients with WD, 5 healthy heterozygote subjects, and 8 healthy controls were injected with an i.v. bolus of 64Cu followed by a 90-min dynamic PET scan of the liver and static whole-body PET/CT scans after 1.5, 6, and 20 h. Blood 64Cu concentrations were measured in parallel. Hepatic copper retention and redistribution were evaluated by standardized uptake values (SUVs). At 90 min, hepatic SUVs were similar in the three groups. In contrast, at 20 h postinjection, the SUV in WD patients (mean ± SEM, 31 ± 4) was higher than in heterozygotes (24 ± 3) and controls (21 ± 4; p < 0.001). An SUV-ratio of hepatic 64Cu concentration at 20 and 1.5 h completely discriminated between WD patients and control groups (p < 0.0001; ANOVA). By Patlak analysis of the initial 90 min of the PET scan, the steady-state hepatic clearance of 64Cu was estimated to be slightly lower in patients with WD than in controls (p = 0.04). Conclusions 64Cu PET imaging enables visualization and quantification of the hepatic copper retention characteristic for WD patients. This method represents a valuable tool for future studies of WD pathophysiology, and may assist the development of therapies, and accurate diagnosis." @default.
• W3212419102 created "2021-11-22" @default.
• W3212419102 creator A5005923405 @default.
• W3212419102 creator A5008802527 @default.
• W3212419102 creator A5009620956 @default.
• W3212419102 creator A5014477154 @default.
• W3212419102 creator A5032179758 @default.
• W3212419102 creator A5036235361 @default.
• W3212419102 creator A5036928941 @default.
• W3212419102 creator A5042730065 @default.
• W3212419102 creator A5047632381 @default.
• W3212419102 creator A5062023062 @default.
• W3212419102 creator A5067335445 @default.
• W3212419102 creator A5080741438 @default.
• W3212419102 date "2022-01-10" @default.
• W3212419102 modified "2023-10-01" @default.
• W3212419102 title "The pathophysiology of Wilson’s disease visualized: A human 64Cu PET study" @default.
• W3212419102 cites W1975554388 @default.
• W3212419102 cites W1996610030 @default.
• W3212419102 cites W2032507046 @default.
• W3212419102 cites W2045623736 @default.
• W3212419102 cites W2049520025 @default.
• W3212419102 cites W2051228374 @default.
• W3212419102 cites W2071055102 @default.
• W3212419102 cites W2074274895 @default.
• W3212419102 cites W2078973467 @default.
• W3212419102 cites W2079522949 @default.
• W3212419102 cites W2082140093 @default.
• W3212419102 cites W2134077541 @default.
• W3212419102 cites W2241760375 @default.
• W3212419102 cites W2398695997 @default.
• W3212419102 cites W2398992100 @default.
• W3212419102 cites W2406782250 @default.
• W3212419102 cites W2439035913 @default.
• W3212419102 cites W2752207078 @default.
• W3212419102 cites W2772744872 @default.
• W3212419102 cites W2789798326 @default.
• W3212419102 cites W2890069589 @default.
• W3212419102 cites W2970468982 @default.
• W3212419102 cites W2970874524 @default.
• W3212419102 cites W2991095675 @default.
• W3212419102 cites W3035988444 @default.
• W3212419102 cites W3045075706 @default.
• W3212419102 cites W3212080551 @default.
• W3212419102 cites W3212419102 @default.
• W3212419102 cites W4211041131 @default.
• W3212419102 cites W4240471350 @default.
• W3212419102 doi "https://doi.org/10.1002/hep.32238" @default.
• W3212419102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34773664" @default.
• W3212419102 hasPublicationYear "2022" @default.
• W3212419102 type Work @default.
• W3212419102 sameAs 3212419102 @default.
• W3212419102 citedByCount "12" @default.
• W3212419102 countsByYear W32124191022022 @default.
• W3212419102 countsByYear W32124191022023 @default.
• W3212419102 crossrefType "journal-article" @default.
• W3212419102 hasAuthorship W3212419102A5005923405 @default.
• W3212419102 hasAuthorship W3212419102A5008802527 @default.
• W3212419102 hasAuthorship W3212419102A5009620956 @default.
• W3212419102 hasAuthorship W3212419102A5014477154 @default.
• W3212419102 hasAuthorship W3212419102A5032179758 @default.
• W3212419102 hasAuthorship W3212419102A5036235361 @default.
• W3212419102 hasAuthorship W3212419102A5036928941 @default.
• W3212419102 hasAuthorship W3212419102A5042730065 @default.
• W3212419102 hasAuthorship W3212419102A5047632381 @default.
• W3212419102 hasAuthorship W3212419102A5062023062 @default.
• W3212419102 hasAuthorship W3212419102A5067335445 @default.
• W3212419102 hasAuthorship W3212419102A5080741438 @default.
• W3212419102 hasBestOaLocation W32124191021 @default.
• W3212419102 hasConcept C10162356 @default.
• W3212419102 hasConcept C104317684 @default.
• W3212419102 hasConcept C126322002 @default.
• W3212419102 hasConcept C153471976 @default.
• W3212419102 hasConcept C180754005 @default.
• W3212419102 hasConcept C185592680 @default.
• W3212419102 hasConcept C2775842073 @default.
• W3212419102 hasConcept C2776231509 @default.
• W3212419102 hasConcept C2779134260 @default.
• W3212419102 hasConcept C2989005 @default.
• W3212419102 hasConcept C55493867 @default.
• W3212419102 hasConcept C71924100 @default.
• W3212419102 hasConcept C90924648 @default.
• W3212419102 hasConceptScore W3212419102C10162356 @default.
• W3212419102 hasConceptScore W3212419102C104317684 @default.
• W3212419102 hasConceptScore W3212419102C126322002 @default.
• W3212419102 hasConceptScore W3212419102C153471976 @default.
• W3212419102 hasConceptScore W3212419102C180754005 @default.
• W3212419102 hasConceptScore W3212419102C185592680 @default.
• W3212419102 hasConceptScore W3212419102C2775842073 @default.
• W3212419102 hasConceptScore W3212419102C2776231509 @default.
• W3212419102 hasConceptScore W3212419102C2779134260 @default.
• W3212419102 hasConceptScore W3212419102C2989005 @default.
• W3212419102 hasConceptScore W3212419102C55493867 @default.
• W3212419102 hasConceptScore W3212419102C71924100 @default.
• W3212419102 hasConceptScore W3212419102C90924648 @default.
• W3212419102 hasIssue "6" @default.
• W3212419102 hasLocation W32124191021 @default.
• W3212419102 hasLocation W32124191022 @default.

• next