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• W3212453971 abstract "The role of normal sensory inputs in the development of sensory cortices is well known, however, their impacts on the hippocampus, an integrator of sensory modalities with important roles in cognitive functions, has received much less attention. Here, we applied a long-term sensory deprivation paradigm by trimming the rats' whiskers bilaterally, from postnatal day 3 to 59. Female sensory-deprived (SD) rats showed more on-wall rearing and visits to the center of the open-field box, shorter periods of grooming, less defecation and less anxiety-like behaviors in the elevated plus-maze compared to controls, who had their intact whiskers brushed. Passive avoidance memory retention was sex-dependently impaired in the female SD rats. In the radial arm maze, however, reference spatial memory was impaired only in the male SD rats. Nonetheless, working memory errors increased in both sexes of SD rats. Besides depletion of CA1 and CA3 pyramidal neurons in SD rats, Sholl analysis of Golgi-Cox stained neurons revealed that prolonged sensory deprivation has retracted the arborization of CA1 basal dendrites in SD group, while solely female SD rats had diminished CA1 apical dendrites. Sholl analysis of CA3 neurons in SD animals also disclosed significantly more branched apical dendrites in males and basal dendrites in females. Sensory deprivation also led to a considerable spine loss and variation of different spine types in a sex-dependent manner. Our findings suggest that experience-dependent structural plasticity is capable of spreading far beyond the manipulated sensory zones and the inevitable functional alterations can be expressed in a multifactorial sex-dependent manner." @default.
• W3212453971 created "2021-11-22" @default.
• W3212453971 creator A5064527739 @default.
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• W3212453971 date "2021-11-01" @default.
• W3212453971 modified "2023-09-23" @default.
• W3212453971 title "Long-lasting postnatal sensory deprivation alters dendritic morphology of pyramidal neurons in the rat hippocampus: behavioral correlates" @default.
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• W3212453971 doi "https://doi.org/10.1016/j.neuroscience.2021.11.011" @default.
• W3212453971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34785272" @default.
• W3212453971 hasPublicationYear "2021" @default.
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