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• W3212605903 abstract "Tacrolimus (FK506) and rapamycin (RAPA) are widely used to maintain long-term immunosuppression after organ transplantation. However, the impact of accumulative drug administration on the recipients’ immune systems remains unclear. We investigated the impact of 3-year FK506 or RAPA treatment after renal transplantation on the human immune systems. A discovery cohort of 30 patients was first recruited, and we discovered two distinctive T lineage suppressive regulatory patterns induced by chronic treatment of FK506 and RAPA. The increased percentage of senescent CD8+CD57+ T lineages and less responsive T cell receptor (TCR) pathway in the FK506 group indicate better graft acceptance. Meanwhile, percentages of regulatory T cells (Tregs) and expression of CTLA-4 were both up to two-fold higher in the RAPA group, suggesting the inconsistent reactivation potential of the FK506 and RAPA groups when an anti-tumour or anti-infection immune response is concerned. Additionally, up-regulation of phosphorylated signaling proteins in T lineages after in vitro CD3/CD28 stimulation suggested more sensitive TCR-signaling pathways reserved in the RAPA group. An independent validation cohort of 100 renal transplantation patients was further investigated for the hypothesis that long-term RAPA administration mitigates the development of tumours and infections during long-term intake of immunosuppressants. Our results indicate that RAPA administration indeed results in less clinical oncogenesis and infection. The deep phenotyping of T-cell lineages, as educated by the long-term treatment of different immunosuppressants, provides new evidence for personalized precision medicine after renal transplantations." @default.
• W3212605903 created "2021-11-22" @default.
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• W3212605903 date "2021-11-01" @default.
• W3212605903 modified "2023-10-15" @default.
• W3212605903 title "Deep phenotyping of T cell populations under long‐term treatment of tacrolimus and rapamycin in patients receiving renal transplantations by mass cytometry" @default.
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• W3212605903 cites W1558352705 @default.
• W3212605903 cites W1565046736 @default.
• W3212605903 cites W1593813009 @default.
• W3212605903 cites W1631661663 @default.
• W3212605903 cites W1910012553 @default.
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• W3212605903 cites W1981298448 @default.
• W3212605903 cites W1993835819 @default.
• W3212605903 cites W1995311442 @default.
• W3212605903 cites W1998312537 @default.
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• W3212605903 cites W2001172799 @default.
• W3212605903 cites W2002641565 @default.
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• W3212605903 cites W2010121414 @default.
• W3212605903 cites W2017455926 @default.
• W3212605903 cites W2024626836 @default.
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• W3212605903 cites W2048810850 @default.
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• W3212605903 doi "https://doi.org/10.1002/ctm2.629" @default.
• W3212605903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8574956" @default.
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• W3212605903 hasPublicationYear "2021" @default.
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