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- W3212631762 endingPage "124" @default.
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- W3212631762 abstract "Pain is the major non-motor symptom in Parkinson's disease (PD). Preclinical studies have mostly investigated mechanical pain by considering the decrease in a nociceptive threshold. Only a few studies have focused on thermal pain in animal models of PD. Therefore, the goal of this study was to assess the thermal nociceptive behavior of rats subjected to 6-hydroxydopamine (6-OHDA) administration, which constitutes an animal model of PD. Thermal plate investigation demonstrated significant thermal sensitivity to cold temperatures of 10 °C and 15 °C, and not to higher temperatures, in 6-OHDA-lesioned rats when compared with sham. 6-OHDA-lesioned rats also showed cold allodynia as demonstrated by a significant difference in the number of flinches, latency and reaction time to acetone stimulus. Ropinirole administration, a dopamine receptor 2 (D2R) agonist, blocked the acetone-induced cold allodynia in 6-OHDA-lesioned rats. In addition, mechanical hypersensitivity and static allodynia, as demonstrated by a significant difference in the vocalization threshold and pain score respectively, were noticed in 6-OHDA-lesioned rats. Acetone stimulus induced a significant increase in extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) phosphorylation, a pain process molecular marker, in the spinal dorsal horn (SDH), the insular and cingulate cortices in 6-OHDA-lesioned rats when compared to sham. In 6-OHDA-lesioned rats, there was a significant augmentation in the expression of both protein kinase C gamma (PKCγ) and glutamate decarboxylase 67 (GAD67) in the SDH. This highlighted an increase in excitation and a decrease in inhibition in the SDH. Overall, the present study demonstrated a clear cold thermal hypersensitivity, in addition to a mechanical one, in 6-OHDA-lesioned rats." @default.
- W3212631762 created "2021-11-22" @default.
- W3212631762 creator A5008012573 @default.
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- W3212631762 creator A5058948419 @default.
- W3212631762 creator A5063518848 @default.
- W3212631762 creator A5078352037 @default.
- W3212631762 date "2021-12-01" @default.
- W3212631762 modified "2023-09-29" @default.
- W3212631762 title "Behavioral, Cellular and Molecular Responses to Cold and Mechanical Stimuli in Rats with Bilateral Dopamine Depletion in the Mesencephalic Dopaminergic Neurons" @default.
- W3212631762 cites W1530030261 @default.
- W3212631762 cites W1678465678 @default.
- W3212631762 cites W1731568533 @default.
- W3212631762 cites W1938504945 @default.
- W3212631762 cites W1964486755 @default.
- W3212631762 cites W1964600015 @default.
- W3212631762 cites W1966688035 @default.
- W3212631762 cites W1967584588 @default.
- W3212631762 cites W1967677380 @default.
- W3212631762 cites W1967849926 @default.
- W3212631762 cites W1968530473 @default.
- W3212631762 cites W1972075157 @default.
- W3212631762 cites W1978174847 @default.
- W3212631762 cites W1980567992 @default.
- W3212631762 cites W1980571433 @default.
- W3212631762 cites W1982644673 @default.
- W3212631762 cites W1982660778 @default.
- W3212631762 cites W1994305836 @default.
- W3212631762 cites W1996379537 @default.
- W3212631762 cites W2000781717 @default.
- W3212631762 cites W2001343658 @default.
- W3212631762 cites W2003628930 @default.
- W3212631762 cites W2004983430 @default.
- W3212631762 cites W2009387181 @default.
- W3212631762 cites W2010584945 @default.
- W3212631762 cites W2013326835 @default.
- W3212631762 cites W2021213398 @default.
- W3212631762 cites W2022302423 @default.
- W3212631762 cites W2024762752 @default.
- W3212631762 cites W2027387120 @default.
- W3212631762 cites W2030115333 @default.
- W3212631762 cites W2031051134 @default.
- W3212631762 cites W2031678730 @default.
- W3212631762 cites W2031811175 @default.
- W3212631762 cites W2039519643 @default.
- W3212631762 cites W2042544503 @default.
- W3212631762 cites W2042884384 @default.
- W3212631762 cites W2042950525 @default.
- W3212631762 cites W2043323520 @default.
- W3212631762 cites W2044860425 @default.
- W3212631762 cites W2046806142 @default.
- W3212631762 cites W2047218405 @default.
- W3212631762 cites W2047454646 @default.
- W3212631762 cites W2048618617 @default.
- W3212631762 cites W2051131324 @default.
- W3212631762 cites W2057486642 @default.
- W3212631762 cites W2060003600 @default.
- W3212631762 cites W2061505696 @default.
- W3212631762 cites W2065296100 @default.
- W3212631762 cites W2066114516 @default.
- W3212631762 cites W2067071952 @default.
- W3212631762 cites W2067421308 @default.
- W3212631762 cites W2067734511 @default.
- W3212631762 cites W2069010931 @default.
- W3212631762 cites W2069255967 @default.
- W3212631762 cites W2070448722 @default.
- W3212631762 cites W2071334120 @default.
- W3212631762 cites W2073394479 @default.
- W3212631762 cites W2074728653 @default.
- W3212631762 cites W2075003212 @default.
- W3212631762 cites W2077300102 @default.
- W3212631762 cites W2077724459 @default.
- W3212631762 cites W2080855938 @default.
- W3212631762 cites W2080935562 @default.
- W3212631762 cites W2082215577 @default.
- W3212631762 cites W2085301231 @default.
- W3212631762 cites W2098783566 @default.
- W3212631762 cites W2100867723 @default.
- W3212631762 cites W2103677924 @default.
- W3212631762 cites W2111631879 @default.
- W3212631762 cites W2126642279 @default.
- W3212631762 cites W2128692107 @default.
- W3212631762 cites W2135242773 @default.
- W3212631762 cites W2138016793 @default.
- W3212631762 cites W2140115878 @default.
- W3212631762 cites W2143274971 @default.
- W3212631762 cites W2143742981 @default.
- W3212631762 cites W2148389554 @default.
- W3212631762 cites W2149219072 @default.
- W3212631762 cites W2150771878 @default.
- W3212631762 cites W2160569512 @default.
- W3212631762 cites W2166211493 @default.
- W3212631762 cites W2166833085 @default.
- W3212631762 cites W2172201406 @default.
- W3212631762 cites W2286855163 @default.
- W3212631762 cites W2338147507 @default.