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• W3212668738 abstract "Human gastrointestinal malignancies are highly heterogeneous cancers. Clinically, heterogeneity largely contributes to tumor progression and resistance to therapy. Heterogeneity within gastrointestinal cancers is defined by molecular subtypes in genomic and transcriptomic analyses. Cancer stem cells (CSCs) have been demonstrated to be a major source of tumor heterogeneity; therefore, assessing tumor heterogeneity by CSC trait-guided classification of gastrointestinal cancers is essential for the development of effective therapies. CSCs share critical features with embryonic stem cells (ESCs). Molecular investigations have revealed that embryonic genes and developmental signaling pathways regulating the properties of ESCs or cell lineage differentiation are abnormally active and might be oncofetal drivers in certain tumor subtypes. Currently, multiple strategies allow comprehensive identification of tumor subtype-specific oncofetal signatures and evaluation of subtype-specific therapies. In this review, we summarize current knowledge concerning the molecular classification of gastrointestinal malignancies based on CSC features and elucidate their clinical relevance. We also outline strategies for molecular subtype identification and subtype-based therapies. Finally, we explore how clinical implementation of tumor classification by CSC subtype might facilitate the development of more effective personalized therapies for gastrointestinal cancers." @default.
• W3212668738 created "2021-11-22" @default.
• W3212668738 creator A5002470772 @default.
• W3212668738 creator A5012229859 @default.
• W3212668738 creator A5023313887 @default.
• W3212668738 creator A5045797751 @default.
• W3212668738 creator A5065317735 @default.
• W3212668738 date "2021-11-13" @default.
• W3212668738 modified "2023-10-18" @default.
• W3212668738 title "Molecular subclassification of gastrointestinal cancers based on cancer stem cell traits" @default.
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