FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212672299> ?p ?o ?g. }

• W3212672299 endingPage "1405" @default.
• W3212672299 startingPage "1394" @default.
• W3212672299 abstract "Mutations of the isocitrate dehydrogenase-1 (IDH1) and IDH2 genes are among the most frequent alterations in acute myeloid leukemia (AML) and can be found in ∼20% of patients at diagnosis. Among 4930 patients (median age, 56 years; interquartile range, 45-66) with newly diagnosed, intensively treated AML, we identified IDH1 mutations in 423 (8.6%) and IDH2 mutations in 575 (11.7%). Overall, there were no differences in response rates or survival for patients with mutations in IDH1 or IDH2 compared with patients without mutated IDH1/2. However, distinct clinical and comutational phenotypes of the most common subtypes of IDH1/2 mutations could be associated with differences in outcome. IDH1-R132C was associated with increased age, lower white blood cell (WBC) count, less frequent comutation of NPM1 and FLT3 internal tandem mutation (ITD) as well as with lower rate of complete remission and a trend toward reduced overall survival (OS) compared with other IDH1 mutation variants and wild-type (WT) IDH1/2. In our analysis, IDH2-R172K was associated with significantly lower WBC count, more karyotype abnormalities, and less frequent comutations of NPM1 and/or FLT3-ITD. Among patients within the European LeukemiaNet 2017 intermediate- and adverse-risk groups, relapse-free survival and OS were significantly better for those with IDH2-R172K compared with WT IDH, providing evidence that AML with IDH2-R172K could be a distinct entity with a specific comutation pattern and favorable outcome. In summary, the presented data from a large cohort of patients with IDH1/2 mutated AML indicate novel and clinically relevant findings for the most common IDH mutation subtypes." @default.
• W3212672299 created "2021-11-22" @default.
• W3212672299 creator A5004741011 @default.
• W3212672299 creator A5006122560 @default.
• W3212672299 creator A5007449495 @default.
• W3212672299 creator A5010845118 @default.
• W3212672299 creator A5011869549 @default.
• W3212672299 creator A5012020159 @default.
• W3212672299 creator A5014165335 @default.
• W3212672299 creator A5016360607 @default.
• W3212672299 creator A5017002895 @default.
• W3212672299 creator A5017740329 @default.
• W3212672299 creator A5018356664 @default.
• W3212672299 creator A5021974658 @default.
• W3212672299 creator A5022616874 @default.
• W3212672299 creator A5025105470 @default.
• W3212672299 creator A5025165056 @default.
• W3212672299 creator A5026359397 @default.
• W3212672299 creator A5026849709 @default.
• W3212672299 creator A5027358264 @default.
• W3212672299 creator A5027652600 @default.
• W3212672299 creator A5028388949 @default.
• W3212672299 creator A5030808762 @default.
• W3212672299 creator A5033935778 @default.
• W3212672299 creator A5035426042 @default.
• W3212672299 creator A5035964802 @default.
• W3212672299 creator A5037944783 @default.
• W3212672299 creator A5038634249 @default.
• W3212672299 creator A5041814192 @default.
• W3212672299 creator A5044355331 @default.
• W3212672299 creator A5045850647 @default.
• W3212672299 creator A5047829491 @default.
• W3212672299 creator A5048405970 @default.
• W3212672299 creator A5053094064 @default.
• W3212672299 creator A5057452651 @default.
• W3212672299 creator A5061229750 @default.
• W3212672299 creator A5071523133 @default.
• W3212672299 creator A5072021108 @default.
• W3212672299 creator A5073313603 @default.
• W3212672299 creator A5073342980 @default.
• W3212672299 creator A5074354027 @default.
• W3212672299 creator A5078512688 @default.
• W3212672299 creator A5079124367 @default.
• W3212672299 creator A5079605019 @default.
• W3212672299 creator A5083561268 @default.
• W3212672299 creator A5084120623 @default.
• W3212672299 creator A5085830409 @default.
• W3212672299 creator A5086016311 @default.
• W3212672299 date "2022-02-25" @default.
• W3212672299 modified "2023-10-09" @default.
• W3212672299 title "Differential impact of <i>IDH1</i>/<i>2</i> mutational subclasses on outcome in adult AML: results from a large multicenter study" @default.
• W3212672299 cites W1847894796 @default.
• W3212672299 cites W1905022268 @default.
• W3212672299 cites W1971240883 @default.
• W3212672299 cites W1975267683 @default.
• W3212672299 cites W1975705021 @default.
• W3212672299 cites W1990710680 @default.
• W3212672299 cites W1991775451 @default.
• W3212672299 cites W2012588998 @default.
• W3212672299 cites W2022686977 @default.
• W3212672299 cites W2023014046 @default.
• W3212672299 cites W2040395832 @default.
• W3212672299 cites W2051207198 @default.
• W3212672299 cites W2063092678 @default.
• W3212672299 cites W2065464763 @default.
• W3212672299 cites W2066236650 @default.
• W3212672299 cites W2067190888 @default.
• W3212672299 cites W2103798556 @default.
• W3212672299 cites W2111988427 @default.
• W3212672299 cites W2112414163 @default.
• W3212672299 cites W2115707319 @default.
• W3212672299 cites W2116858301 @default.
• W3212672299 cites W2124462726 @default.
• W3212672299 cites W2126817554 @default.
• W3212672299 cites W2127738065 @default.
• W3212672299 cites W2132912591 @default.
• W3212672299 cites W2150319200 @default.
• W3212672299 cites W2152496375 @default.
• W3212672299 cites W2412183643 @default.
• W3212672299 cites W2419140434 @default.
• W3212672299 cites W2530614832 @default.
• W3212672299 cites W2559537906 @default.
• W3212672299 cites W2623089849 @default.
• W3212672299 cites W2782689192 @default.
• W3212672299 cites W2791503783 @default.
• W3212672299 cites W2792029111 @default.
• W3212672299 cites W2806682325 @default.
• W3212672299 cites W2809369313 @default.
• W3212672299 cites W2894296830 @default.
• W3212672299 cites W2979416587 @default.
• W3212672299 cites W2981869008 @default.
• W3212672299 cites W2983697355 @default.
• W3212672299 cites W2985247963 @default.
• W3212672299 cites W2991545584 @default.
• W3212672299 cites W3000515035 @default.
• W3212672299 cites W3028601966 @default.
• W3212672299 cites W3028657131 @default.
• W3212672299 cites W3031916639 @default.

• next