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• W3212698068 endingPage "2970" @default.
• W3212698068 startingPage "2961" @default.
• W3212698068 abstract "The brevetoxins, neurotoxins produced by Karenia brevis, the Florida red tide dinoflagellate, effect fish and wildlife mortalities and adverse public health and economic impacts during recurrent blooms. Knowledge of the biochemical consequences of toxin production for K. brevis could provide insights into an endogenous role of the toxins, yet this aspect has not been thoroughly explored. In addition to neurotoxicity, the most abundant of the brevetoxins, PbTx-2, inhibits mammalian thioredoxin reductase (TrxR). The thioredoxin system, composed of the enzymes TrxR and thioredoxin (Trx), is present in all living organisms and is responsible in part for maintaining cellular redox homeostasis. Herein, we describe the cloning, expression, and semisynthesis of the selenoprotein TrxR from K. brevis (KbTrxR) and reductase activity toward a variety of substrates. Unlike mammalian TrxR, KbTrxR reduces oxidized glutathione (GSSG). We further demonstrate that PbTx-2 is an inhibitor of KbTrxR. Covalent adducts between KbTrxR and rat TrxR were detected by mass spectrometry. While both enzymes are adducted at or near the catalytic centers, the specific residues are distinct. Biochemical differences reported for high and low toxin producing strains of K. brevis are consistent with the inhibition of KbTrxR and suggest that PbTx-2 is an endogenous regulator of this critical enzyme." @default.
• W3212698068 created "2021-11-22" @default.
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• W3212698068 date "2021-11-09" @default.
• W3212698068 modified "2023-09-26" @default.
• W3212698068 title "The Marine Neurotoxin Brevetoxin (PbTx-2) Inhibits <i>Karenia brevis</i> and Mammalian Thioredoxin Reductases by Targeting Different Residues" @default.
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• W3212698068 doi "https://doi.org/10.1021/acs.jnatprod.1c00795" @default.
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• W3212698068 hasPublicationYear "2021" @default.
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