FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212724166> ?p ?o ?g. }

• W3212724166 endingPage "100486" @default.
• W3212724166 startingPage "100486" @default.
• W3212724166 abstract "Although three randomized control trials have proven mortality benefit of CT lung cancer screening (CTLS), <5% of eligible US smokers are screened. Some attribute this to fear of harm conveyed at shared decision visits, including the harm of overdiagnosis/overtreatment of indolent BAC-like adenocarcinoma.Since the frequency of indolent cancers has not been compared between CTLS and routinely detected cohorts, we compare pathology and RNA expression of 86 NCCN high-risk CTLS subjects to 83 high-risk (HR-R) and 51 low-risk (LR-R) routinely detected patients. Indolent adenocarcinoma was defined as previously described for low malignant potential (LMP) adenocarcinoma along with AIS/MIA. Exome RNA sequencing was performed on a subset of high-risk (CTLS and HR-R) FFPE tumor samples.Indolent adenocarcinoma (AIS, MIA, and LMP) showed 100% disease-specific survival (DSS) with similar frequency in CTLS (18%) and HR-R (20%) which were comparatively lower than LR-R (33%). Despite this observation, CTLS exhibited intermediate DSS between HR-R and LR-R (5-year DSS: 88% CTLS, 82% HR-R, & 95% LR-R, p = 0.047), possibly reflecting a 0.4 cm smaller median tumor size and lower frequency of tumor necrosis compared to HR-R. WGCNA gene modules derived from TCGA lung adenocarcinoma correlated with aggressive histologic patterns, mitotic activity, and tumor invasive features, but no significant differential expression between CTLS and HR-R was observed.CTLS subjects are at no greater risk of overdiagnosis from indolent adenocarcinoma (AIS, MIA, and LMP) than risk-matched patients whose cancers are discovered in routine clinical practice. Improved outcomes likely reflect detection and treatment at smaller size." @default.
• W3212724166 created "2021-11-22" @default.
• W3212724166 creator A5005583226 @default.
• W3212724166 creator A5008686381 @default.
• W3212724166 creator A5012357319 @default.
• W3212724166 creator A5016344156 @default.
• W3212724166 creator A5021786359 @default.
• W3212724166 creator A5029050606 @default.
• W3212724166 creator A5038194414 @default.
• W3212724166 creator A5050197783 @default.
• W3212724166 creator A5054580205 @default.
• W3212724166 creator A5059272397 @default.
• W3212724166 creator A5064411059 @default.
• W3212724166 creator A5083571909 @default.
• W3212724166 creator A5085351836 @default.
• W3212724166 creator A5086648663 @default.
• W3212724166 date "2021-01-01" @default.
• W3212724166 modified "2023-10-16" @default.
• W3212724166 title "Pathologic and gene expression comparison of CT- screen detected and routinely detected stage I/0 lung adenocarcinoma in NCCN risk-matched cohorts." @default.
• W3212724166 cites W130099911 @default.
• W3212724166 cites W1966327575 @default.
• W3212724166 cites W1980610830 @default.
• W3212724166 cites W1999574084 @default.
• W3212724166 cites W2107692993 @default.
• W3212724166 cites W2109334944 @default.
• W3212724166 cites W2110254651 @default.
• W3212724166 cites W2114104545 @default.
• W3212724166 cites W2130410032 @default.
• W3212724166 cites W2130430382 @default.
• W3212724166 cites W2137586531 @default.
• W3212724166 cites W2169456326 @default.
• W3212724166 cites W2288794117 @default.
• W3212724166 cites W2289268957 @default.
• W3212724166 cites W2292826896 @default.
• W3212724166 cites W2315914809 @default.
• W3212724166 cites W2340606245 @default.
• W3212724166 cites W2586030734 @default.
• W3212724166 cites W2605897695 @default.
• W3212724166 cites W2802824584 @default.
• W3212724166 cites W2892088279 @default.
• W3212724166 cites W2898384149 @default.
• W3212724166 cites W2901219454 @default.
• W3212724166 cites W2928271642 @default.
• W3212724166 cites W2940469730 @default.
• W3212724166 cites W2977037315 @default.
• W3212724166 cites W3003415550 @default.
• W3212724166 cites W3008871488 @default.
• W3212724166 cites W3048329188 @default.
• W3212724166 cites W3079676645 @default.
• W3212724166 cites W3101873453 @default.
• W3212724166 cites W3106369794 @default.
• W3212724166 cites W3119826852 @default.
• W3212724166 cites W3165430306 @default.
• W3212724166 doi "https://doi.org/10.1016/j.ctarc.2021.100486" @default.
• W3212724166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34794107" @default.
• W3212724166 hasPublicationYear "2021" @default.
• W3212724166 type Work @default.
• W3212724166 sameAs 3212724166 @default.
• W3212724166 citedByCount "0" @default.
• W3212724166 crossrefType "journal-article" @default.
• W3212724166 hasAuthorship W3212724166A5005583226 @default.
• W3212724166 hasAuthorship W3212724166A5008686381 @default.
• W3212724166 hasAuthorship W3212724166A5012357319 @default.
• W3212724166 hasAuthorship W3212724166A5016344156 @default.
• W3212724166 hasAuthorship W3212724166A5021786359 @default.
• W3212724166 hasAuthorship W3212724166A5029050606 @default.
• W3212724166 hasAuthorship W3212724166A5038194414 @default.
• W3212724166 hasAuthorship W3212724166A5050197783 @default.
• W3212724166 hasAuthorship W3212724166A5054580205 @default.
• W3212724166 hasAuthorship W3212724166A5059272397 @default.
• W3212724166 hasAuthorship W3212724166A5064411059 @default.
• W3212724166 hasAuthorship W3212724166A5083571909 @default.
• W3212724166 hasAuthorship W3212724166A5085351836 @default.
• W3212724166 hasAuthorship W3212724166A5086648663 @default.
• W3212724166 hasBestOaLocation W32127241661 @default.
• W3212724166 hasConcept C121608353 @default.
• W3212724166 hasConcept C126322002 @default.
• W3212724166 hasConcept C143998085 @default.
• W3212724166 hasConcept C146357865 @default.
• W3212724166 hasConcept C151730666 @default.
• W3212724166 hasConcept C2776256026 @default.
• W3212724166 hasConcept C2779377019 @default.
• W3212724166 hasConcept C2781182431 @default.
• W3212724166 hasConcept C71924100 @default.
• W3212724166 hasConcept C86803240 @default.
• W3212724166 hasConceptScore W3212724166C121608353 @default.
• W3212724166 hasConceptScore W3212724166C126322002 @default.
• W3212724166 hasConceptScore W3212724166C143998085 @default.
• W3212724166 hasConceptScore W3212724166C146357865 @default.
• W3212724166 hasConceptScore W3212724166C151730666 @default.
• W3212724166 hasConceptScore W3212724166C2776256026 @default.
• W3212724166 hasConceptScore W3212724166C2779377019 @default.
• W3212724166 hasConceptScore W3212724166C2781182431 @default.
• W3212724166 hasConceptScore W3212724166C71924100 @default.
• W3212724166 hasConceptScore W3212724166C86803240 @default.
• W3212724166 hasFunder F4320332161 @default.
• W3212724166 hasLocation W32127241661 @default.
• W3212724166 hasLocation W32127241662 @default.

• next