Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212806500> ?p ?o ?g. }
- W3212806500 abstract "Somatic mutations in APC or CTNNB1 genes lead to aberrant Wnt signaling and colorectal cancer (CRC) initiation and progression via-catenin–T cell factor/lymphoid enhancer binding factor TCF/LEF transcription factors. We found that Lef1 was expressed exclusively in Apc-mutant, Wnt ligand–independent tumors, but not in ligand-dependent, serrated tumors. To analyze Lef1 function in tumor development, we conditionally deleted Lef1 in intestinal stem cells of Apcfl/fl mice or broadly from the entire intestinal epithelium of Apcfl/fl or ApcMin/+ mice. Loss of Lef1 markedly increased tumor initiation and tumor cell proliferation, reduced the expression of several Wnt antagonists, and increased Myc proto-oncogene expression and formation of ectopic crypts in Apc-mutant adenomas. Our results uncover a previously unknown negative feedback mechanism in CRC, in which ectopic Lef1 expression suppresses intestinal tumorigenesis by restricting adenoma cell dedifferentiation to a crypt-progenitor phenotype and by reducing the formation of cancer stem cell niches." @default.
- W3212806500 created "2021-11-22" @default.
- W3212806500 creator A5007234456 @default.
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- W3212806500 date "2021-11-19" @default.
- W3212806500 modified "2023-10-03" @default.
- W3212806500 title "Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas" @default.
- W3212806500 cites W1481438827 @default.
- W3212806500 cites W1586218645 @default.
- W3212806500 cites W1791828066 @default.
- W3212806500 cites W1846418786 @default.
- W3212806500 cites W1934094702 @default.
- W3212806500 cites W1972778166 @default.
- W3212806500 cites W1975305533 @default.
- W3212806500 cites W1976566521 @default.
- W3212806500 cites W1978881608 @default.
- W3212806500 cites W1981766282 @default.
- W3212806500 cites W1982603620 @default.
- W3212806500 cites W1985886021 @default.
- W3212806500 cites W1992372073 @default.
- W3212806500 cites W1993522288 @default.
- W3212806500 cites W1994216131 @default.
- W3212806500 cites W1997877243 @default.
- W3212806500 cites W2007717461 @default.
- W3212806500 cites W2007990146 @default.
- W3212806500 cites W2014748872 @default.
- W3212806500 cites W2017632960 @default.
- W3212806500 cites W2017828716 @default.
- W3212806500 cites W2027873459 @default.
- W3212806500 cites W2031372290 @default.
- W3212806500 cites W2033420737 @default.
- W3212806500 cites W2036902253 @default.
- W3212806500 cites W2037963573 @default.
- W3212806500 cites W2038143310 @default.
- W3212806500 cites W2038714514 @default.
- W3212806500 cites W2046881486 @default.
- W3212806500 cites W2049792810 @default.
- W3212806500 cites W2052910931 @default.
- W3212806500 cites W2055824128 @default.
- W3212806500 cites W2060515414 @default.
- W3212806500 cites W2061644007 @default.
- W3212806500 cites W2061965920 @default.
- W3212806500 cites W2066362124 @default.
- W3212806500 cites W2067526109 @default.
- W3212806500 cites W2078591745 @default.
- W3212806500 cites W2090562908 @default.
- W3212806500 cites W2090789702 @default.
- W3212806500 cites W2095325198 @default.
- W3212806500 cites W2095692554 @default.
- W3212806500 cites W2097959454 @default.
- W3212806500 cites W2115613693 @default.
- W3212806500 cites W2128781156 @default.
- W3212806500 cites W2134359750 @default.
- W3212806500 cites W2135900256 @default.
- W3212806500 cites W2139419405 @default.
- W3212806500 cites W2141873881 @default.
- W3212806500 cites W2143625921 @default.
- W3212806500 cites W2146167376 @default.
- W3212806500 cites W2148230100 @default.
- W3212806500 cites W2149022033 @default.
- W3212806500 cites W2149468135 @default.
- W3212806500 cites W2151436498 @default.
- W3212806500 cites W2153618863 @default.
- W3212806500 cites W2157010562 @default.
- W3212806500 cites W2157910818 @default.
- W3212806500 cites W2162756888 @default.
- W3212806500 cites W2171507631 @default.
- W3212806500 cites W2171996338 @default.
- W3212806500 cites W2290845417 @default.
- W3212806500 cites W2544638457 @default.
- W3212806500 cites W2567946031 @default.
- W3212806500 cites W2591975886 @default.
- W3212806500 cites W2598830924 @default.
- W3212806500 cites W2617865703 @default.
- W3212806500 cites W2624901980 @default.
- W3212806500 cites W2624980219 @default.
- W3212806500 cites W2767423581 @default.
- W3212806500 cites W2794480084 @default.
- W3212806500 cites W2794521141 @default.
- W3212806500 cites W2914794731 @default.
- W3212806500 cites W2976026968 @default.
- W3212806500 cites W3004730319 @default.
- W3212806500 cites W3008445071 @default.
- W3212806500 cites W3100750497 @default.
- W3212806500 cites W3114133415 @default.
- W3212806500 cites W3165366231 @default.