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• W3212822525 endingPage "6757" @default.
• W3212822525 startingPage "6757" @default.
• W3212822525 abstract "Industrially, after the removal of oil from perilla seeds (PS) by screw-type compression, the large quantities of residual perilla seed meal (PSM) becomes non-valuable waste. Therefore, to increase the health value and price of PS and PSM, we focused on the biological effects of perilla seed oil (PSO) and rosmarinic acid-rich fraction (RA-RF) extracted from PSM for their role in preventing oxidative stress and inflammation caused by TNF-α exposure in an A549 lung adenocarcinoma culture model. The A549 cells were pretreated with PSO or RA-RF and followed by TNF-α treatment. We found that PSO and RA-RF were not toxic to TNF-α-induced A549 cells. Both extracts significantly decreased the generation of reactive oxygen species (ROS) in this cell line. The mRNA expression levels of IL-1β, IL-6, IL-8, TNF-α, and COX-2 were significantly decreased by the treatment of PSO and RA-RF. The Western blot indicated that the expression of MnSOD, FOXO1, and NF-κB and phosphorylation of JNK were also significantly diminished by PSO and RA-RF treatment. The results demonstrated that PSO and RA-RF act as antioxidants to scavenge TNF-α induced ROS levels, resulting in decreased the expression of MnSOD, FOXO1, NF-κB and JNK signaling pathway in a human lung cell culture exposed to TNF-α." @default.
• W3212822525 created "2021-11-22" @default.
• W3212822525 creator A5000017910 @default.
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• W3212822525 date "2021-11-09" @default.
• W3212822525 modified "2023-10-16" @default.
• W3212822525 title "Molecular Mechanism of Antioxidant and Anti-Inflammatory Effects of Omega-3 Fatty Acids in Perilla Seed Oil and Rosmarinic Acid Rich Fraction Extracted from Perilla Seed Meal on TNF-α Induced A549 Lung Adenocarcinoma Cells" @default.
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• W3212822525 doi "https://doi.org/10.3390/molecules26226757" @default.
• W3212822525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8622939" @default.
• W3212822525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34833849" @default.
• W3212822525 hasPublicationYear "2021" @default.
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