FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212834968> ?p ?o ?g. }

• W3212834968 abstract "Abstract Background Ganciclovir pharmacokinetics is characterized by a high variability in drug exposure. Usually, monitoring of ganciclovir exposure is performed by measuring trough concentration. However, due to the specificity of pediatric pharmacokinetics, trough concentration measurements may not be a relevant surrogate of ganciclovir exposure. Area under the curve of concentration (AUC) may be a more appropriate biomarker. Case presentation We report the case of 3.6-year-old boy with Emberger syndrome with a cytomegalovirus reactivation occurring after allogenic hematopoietic stem cell transplantation. After a few days of treatment with intravenous ganciclovir, sub-therapeutic trough ganciclovir concentrations were measured (< 0.5 µg/mL) and viral load still increased. Ganciclovir dosage was increased by two-fold to deal with this treatment failure. Trough concentrations remained sub-therapeutic. The patient had hematologic disorder therefore it was decided to estimate ganciclovir AUC to assess more accurately drug exposure before any further dosage modification. AUC 0–12 h was measured at 51 μg h/mL, which was within the therapeutic range (40–60 μg h/mL). Afterward, viral load decreased and became undetectable. Conclusions This case report highlights that monitoring ganciclovir exposure based on AUC should be performed to tailor drug dosage in order to improve treatment efficacy and safety in pediatric patients." @default.
• W3212834968 created "2021-11-22" @default.
• W3212834968 creator A5004718649 @default.
• W3212834968 creator A5031891241 @default.
• W3212834968 creator A5032223222 @default.
• W3212834968 creator A5038357548 @default.
• W3212834968 creator A5039230447 @default.
• W3212834968 creator A5073306699 @default.
• W3212834968 creator A5089652964 @default.
• W3212834968 date "2021-11-08" @default.
• W3212834968 modified "2023-10-15" @default.
• W3212834968 title "The need for area under the curve measurements in the field of ganciclovir therapeutic drug monitoring in children: a case report" @default.
• W3212834968 cites W1977695988 @default.
• W3212834968 cites W2014540155 @default.
• W3212834968 cites W2034752116 @default.
• W3212834968 cites W2063622588 @default.
• W3212834968 cites W2151812098 @default.
• W3212834968 cites W2157039730 @default.
• W3212834968 cites W2286127041 @default.
• W3212834968 cites W2408443406 @default.
• W3212834968 cites W2898483126 @default.
• W3212834968 cites W2907734794 @default.
• W3212834968 cites W3036975907 @default.
• W3212834968 cites W3202017675 @default.
• W3212834968 doi "https://doi.org/10.1186/s12879-021-06828-8" @default.
• W3212834968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8573890" @default.
• W3212834968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34749667" @default.
• W3212834968 hasPublicationYear "2021" @default.
• W3212834968 type Work @default.
• W3212834968 sameAs 3212834968 @default.
• W3212834968 citedByCount "3" @default.
• W3212834968 countsByYear W32128349682022 @default.
• W3212834968 countsByYear W32128349682023 @default.
• W3212834968 crossrefType "journal-article" @default.
• W3212834968 hasAuthorship W3212834968A5004718649 @default.
• W3212834968 hasAuthorship W3212834968A5031891241 @default.
• W3212834968 hasAuthorship W3212834968A5032223222 @default.
• W3212834968 hasAuthorship W3212834968A5038357548 @default.
• W3212834968 hasAuthorship W3212834968A5039230447 @default.
• W3212834968 hasAuthorship W3212834968A5073306699 @default.
• W3212834968 hasAuthorship W3212834968A5089652964 @default.
• W3212834968 hasBestOaLocation W32128349681 @default.
• W3212834968 hasConcept C112705442 @default.
• W3212834968 hasConcept C126322002 @default.
• W3212834968 hasConcept C19831878 @default.
• W3212834968 hasConcept C203014093 @default.
• W3212834968 hasConcept C2522874641 @default.
• W3212834968 hasConcept C2777408962 @default.
• W3212834968 hasConcept C2777965375 @default.
• W3212834968 hasConcept C2779820661 @default.
• W3212834968 hasConcept C2780035454 @default.
• W3212834968 hasConcept C2780272996 @default.
• W3212834968 hasConcept C2909675724 @default.
• W3212834968 hasConcept C2910800852 @default.
• W3212834968 hasConcept C2911091166 @default.
• W3212834968 hasConcept C31785415 @default.
• W3212834968 hasConcept C71924100 @default.
• W3212834968 hasConcept C76318530 @default.
• W3212834968 hasConcept C98274493 @default.
• W3212834968 hasConceptScore W3212834968C112705442 @default.
• W3212834968 hasConceptScore W3212834968C126322002 @default.
• W3212834968 hasConceptScore W3212834968C19831878 @default.
• W3212834968 hasConceptScore W3212834968C203014093 @default.
• W3212834968 hasConceptScore W3212834968C2522874641 @default.
• W3212834968 hasConceptScore W3212834968C2777408962 @default.
• W3212834968 hasConceptScore W3212834968C2777965375 @default.
• W3212834968 hasConceptScore W3212834968C2779820661 @default.
• W3212834968 hasConceptScore W3212834968C2780035454 @default.
• W3212834968 hasConceptScore W3212834968C2780272996 @default.
• W3212834968 hasConceptScore W3212834968C2909675724 @default.
• W3212834968 hasConceptScore W3212834968C2910800852 @default.
• W3212834968 hasConceptScore W3212834968C2911091166 @default.
• W3212834968 hasConceptScore W3212834968C31785415 @default.
• W3212834968 hasConceptScore W3212834968C71924100 @default.
• W3212834968 hasConceptScore W3212834968C76318530 @default.
• W3212834968 hasConceptScore W3212834968C98274493 @default.
• W3212834968 hasIssue "1" @default.
• W3212834968 hasLocation W32128349681 @default.
• W3212834968 hasLocation W32128349682 @default.
• W3212834968 hasLocation W32128349683 @default.
• W3212834968 hasLocation W32128349684 @default.
• W3212834968 hasLocation W32128349685 @default.
• W3212834968 hasLocation W32128349686 @default.
• W3212834968 hasLocation W32128349687 @default.
• W3212834968 hasLocation W32128349688 @default.
• W3212834968 hasLocation W32128349689 @default.
• W3212834968 hasOpenAccess W3212834968 @default.
• W3212834968 hasPrimaryLocation W32128349681 @default.
• W3212834968 hasRelatedWork W2057605178 @default.
• W3212834968 hasRelatedWork W2065933810 @default.
• W3212834968 hasRelatedWork W2140000173 @default.
• W3212834968 hasRelatedWork W2348254134 @default.
• W3212834968 hasRelatedWork W2937193762 @default.
• W3212834968 hasRelatedWork W2975739768 @default.
• W3212834968 hasRelatedWork W2983691758 @default.
• W3212834968 hasRelatedWork W3134994180 @default.
• W3212834968 hasRelatedWork W4379615125 @default.
• W3212834968 hasRelatedWork W4381706042 @default.
• W3212834968 hasVolume "21" @default.
• W3212834968 isParatext "false" @default.

• next