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- W3212857100 abstract "Comprehensive Summary Chemical investigation of Beauveria felina , a marine‐derived entomopathogenic fungus, obtained two new destruxin hexadepsipeptides (1 and 2) containing an L ‐Ala 5 residue instead of the usual N ‐Me‐ L ‐Ala 5 . Interestingly, the presence of the L ‐Ala 5 residue enabled two slowly‐exchanging solution conformers with cis / trans (ILE 3 )‐( N ‐Me‐Val 4 ) amide bond for 1 and 2 with 1.5 : 1 and 1 : 1 cis / trans ratios, respectively, while only the conformer with cis amide bond was found in the solid‐state. The solution and solid‐state conformers were studied by NMR, X‐ray diffraction and solution and solid‐state ECD measurements, as well as by TDDFT‐ECD calculations. Structural (conformational) parameter‐activity correlations suggested that the extended destruxin geometry with the preferred cis (ILE 3 )‐( N ‐Me‐Val 4 ) bond probably resulted in improved bioactivity and reduced toxicity for the destruxin class. This was the first report on the interconversion phenomenon of cis / trans amide bonds of destruxin class, which could give insights in the development of bioactive destruxin agents with lower toxicity." @default.
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- W3212857100 date "2021-12-18" @default.
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- W3212857100 title "Experimental and Computational Analysis of the Solution and <scp>Solid‐State</scp> Conformations of Hexadepsipeptides from <i>Beauveria felina</i>" @default.
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- W3212857100 doi "https://doi.org/10.1002/cjoc.202100586" @default.
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