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- W3212858760 abstract "Complexes incorporating a threading anthraquinone intercalator with pyrrole lexitropsin and platinum(II) moieties attached were developed with the goal of generating novel DNA binding modes, including the targeting of AT-rich regions in order to have high cytotoxicities. The binding of the complexes to DNA has been investigated and profiles surprisingly similar to that for cisplatin were observed; the profiles were different to those for a complex lacking the pyrrole lexitropsin component. The lack of selective binding to AT-rich regions suggests the platinum binding was dominating the sequence selectivity, and is consistent with the pyrrole lexitropsin slowing intercalation. The DNA unwinding profiles following platinum binding were evaluated by gel electrophoresis and suggested that intercalation and platinum binding were both occurring." @default.
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- W3212858760 date "2021-01-01" @default.
- W3212858760 modified "2023-10-14" @default.
- W3212858760 title "Platinum binding preferences dominate the binding of novel polyamide amidine anthraquinone platinum(<scp>ii</scp>) complexes to DNA" @default.
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- W3212858760 doi "https://doi.org/10.1039/d1dt03539h" @default.
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