Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212912043> ?p ?o ?g. }
- W3212912043 abstract "Cyclic GMP-AMP synthase (cGAS) functions as a key sensor for microbial invasion and cellular damage by detecting emerging cytosolic DNA. Here, we report that GTPase-activating protein-(SH3 domain)-binding protein 1 (G3BP1) primes cGAS for its prompt activation by engaging cGAS in a primary liquid-phase condensation state. Using high-resolution microscopy, we show that in resting cells, cGAS exhibits particle-like morphological characteristics, which are markedly weakened when G3BP1 is deleted. Upon DNA challenge, the pre-condensed cGAS undergoes liquid-liquid phase separation (LLPS) more efficiently. Importantly, G3BP1 deficiency or its inhibition dramatically diminishes DNA-induced LLPS and the subsequent activation of cGAS. Interestingly, RNA, previously reported to form condensates with cGAS, does not activate cGAS. Accordingly, we find that DNA - but not RNA - treatment leads to the dissociation of G3BP1 from cGAS. Taken together, our study shows that the primary condensation state of cGAS is critical for its rapid response to DNA." @default.
- W3212912043 created "2021-11-22" @default.
- W3212912043 creator A5016280362 @default.
- W3212912043 creator A5016620207 @default.
- W3212912043 creator A5017676873 @default.
- W3212912043 creator A5020470912 @default.
- W3212912043 creator A5029506792 @default.
- W3212912043 creator A5029567453 @default.
- W3212912043 creator A5029765784 @default.
- W3212912043 creator A5031553447 @default.
- W3212912043 creator A5034619275 @default.
- W3212912043 creator A5035967912 @default.
- W3212912043 creator A5036324254 @default.
- W3212912043 creator A5046573249 @default.
- W3212912043 creator A5048069725 @default.
- W3212912043 creator A5052022256 @default.
- W3212912043 creator A5056609542 @default.
- W3212912043 creator A5061082958 @default.
- W3212912043 creator A5061396145 @default.
- W3212912043 creator A5064264102 @default.
- W3212912043 creator A5073531557 @default.
- W3212912043 creator A5077262850 @default.
- W3212912043 creator A5090462767 @default.
- W3212912043 creator A5090637113 @default.
- W3212912043 creator A5090728786 @default.
- W3212912043 creator A5091453336 @default.
- W3212912043 date "2021-11-15" @default.
- W3212912043 modified "2023-10-17" @default.
- W3212912043 title "The stress granule protein G3BP1 promotes pre‐condensation of cGAS to allow rapid responses to DNA" @default.
- W3212912043 cites W1504179404 @default.
- W3212912043 cites W1542158376 @default.
- W3212912043 cites W1559117436 @default.
- W3212912043 cites W1614488569 @default.
- W3212912043 cites W1667606852 @default.
- W3212912043 cites W1894813487 @default.
- W3212912043 cites W1936657395 @default.
- W3212912043 cites W1963774361 @default.
- W3212912043 cites W1965260815 @default.
- W3212912043 cites W1977504104 @default.
- W3212912043 cites W1991436313 @default.
- W3212912043 cites W1993832002 @default.
- W3212912043 cites W1994354351 @default.
- W3212912043 cites W2006600110 @default.
- W3212912043 cites W2016131266 @default.
- W3212912043 cites W2017710096 @default.
- W3212912043 cites W2025268177 @default.
- W3212912043 cites W2031182394 @default.
- W3212912043 cites W2040527513 @default.
- W3212912043 cites W2042433863 @default.
- W3212912043 cites W2044821390 @default.
- W3212912043 cites W2059601858 @default.
- W3212912043 cites W2060004514 @default.
- W3212912043 cites W2070785261 @default.
- W3212912043 cites W2071556127 @default.
- W3212912043 cites W2088967588 @default.
- W3212912043 cites W2090998580 @default.
- W3212912043 cites W2091144643 @default.
- W3212912043 cites W2099610218 @default.
- W3212912043 cites W2110739636 @default.
- W3212912043 cites W2123645680 @default.
- W3212912043 cites W2124318814 @default.
- W3212912043 cites W2124651203 @default.
- W3212912043 cites W2130905062 @default.
- W3212912043 cites W2144652247 @default.
- W3212912043 cites W2150860983 @default.
- W3212912043 cites W2165748936 @default.
- W3212912043 cites W2170295495 @default.
- W3212912043 cites W2177646845 @default.
- W3212912043 cites W2318777795 @default.
- W3212912043 cites W2402791934 @default.
- W3212912043 cites W2416403255 @default.
- W3212912043 cites W2520054346 @default.
- W3212912043 cites W2533664860 @default.
- W3212912043 cites W2586927752 @default.
- W3212912043 cites W2588219496 @default.
- W3212912043 cites W2593862218 @default.
- W3212912043 cites W2595869676 @default.
- W3212912043 cites W2646467224 @default.
- W3212912043 cites W2754087313 @default.
- W3212912043 cites W2769039165 @default.
- W3212912043 cites W2781409644 @default.
- W3212912043 cites W2782130029 @default.
- W3212912043 cites W2794654572 @default.
- W3212912043 cites W2795547920 @default.
- W3212912043 cites W2799824986 @default.
- W3212912043 cites W2799828802 @default.
- W3212912043 cites W2808121690 @default.
- W3212912043 cites W2854081253 @default.
- W3212912043 cites W2883701024 @default.
- W3212912043 cites W2901337826 @default.
- W3212912043 cites W2910314419 @default.
- W3212912043 cites W2914907359 @default.
- W3212912043 cites W2916717448 @default.
- W3212912043 cites W2917703782 @default.
- W3212912043 cites W2947823402 @default.
- W3212912043 cites W2968420099 @default.
- W3212912043 cites W2980567099 @default.
- W3212912043 cites W2990332431 @default.
- W3212912043 cites W3004533093 @default.
- W3212912043 cites W3005263787 @default.