Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212912192> ?p ?o ?g. }
- W3212912192 endingPage "11" @default.
- W3212912192 startingPage "1" @default.
- W3212912192 abstract "Interleukin 2 (IL-2) plays a fundamental role in both immune activation and tolerance and has revolutionized the field of cancer immunotherapy since its discovery. The ability of IL-2 to mediate tumor regression in preclinical and clinical settings led to FDA approval for its use in the treatment of metastatic renal cell carcinoma and metastatic melanoma in the 1990s. Although modest success is observed in the clinic, cancer patients receiving IL-2 therapy experience a wide array of side effects ranging from flu-like symptoms to life-threatening conditions such as vascular leak syndrome. Over the past three decades, efforts have focused on circumventing IL-2-related toxicities by engineering methods to localize IL-2 to the tumor or secondary lymphoid tissue, preferentially activate CD8+ T cells and NK cells, and alter pharmacokinetic properties to increase bioavailability. This review summarizes the various IL-2-based strategies that have emerged, with a focus on chimeric fusion methods." @default.
- W3212912192 created "2021-11-22" @default.
- W3212912192 creator A5003534152 @default.
- W3212912192 creator A5016923947 @default.
- W3212912192 creator A5051921899 @default.
- W3212912192 date "2021-11-08" @default.
- W3212912192 modified "2023-10-15" @default.
- W3212912192 title "Interleukin 2-Based Fusion Proteins for the Treatment of Cancer" @default.
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