Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212938802> ?p ?o ?g. }
- W3212938802 endingPage "2577" @default.
- W3212938802 startingPage "2568" @default.
- W3212938802 abstract "Defining and visualizing the three-dimensional (3D) structures of pharmaceuticals provides a new and important tool to elucidate the phenomenal behavior and underlying mechanisms of drug delivery systems. The mechanism of drug release from complex structured dosage forms, such as bilayer osmotic pump tablets, has not been investigated widely for most solid 3D structures. In this study, bilayer osmotic pump tablets undergoing dissolution, as well as after dissolution in a desiccated solid state were examined, and visualized by synchrotron radiation micro-computed tomography (SR-μCT). In situ formed 3D structures at different in vitro drug release states were characterized comprehensively. A distinct movement pattern of NaCl crystals from the push layer to the drug layer was observed, beneath the semi-permeable coating in the desiccated tablet samples. The 3D structures at different dissolution time revealed that the pushing upsurge in the bilayer osmotic pump tablet was directed via peripheral “roadways”. Typically, different regions of the osmotic front, infiltration region, and dormant region were classified in the push layer during the dissolution of drug from tablet samples. According to the observed 3D microstructures, a “subterranean river model” for the drug release mechanism has been defined to explain the drug release mechanism." @default.
- W3212938802 created "2021-11-22" @default.
- W3212938802 creator A5000118586 @default.
- W3212938802 creator A5001629550 @default.
- W3212938802 creator A5003581530 @default.
- W3212938802 creator A5014815673 @default.
- W3212938802 creator A5026252895 @default.
- W3212938802 creator A5026614129 @default.
- W3212938802 creator A5027835055 @default.
- W3212938802 creator A5038430937 @default.
- W3212938802 creator A5039667666 @default.
- W3212938802 creator A5045979088 @default.
- W3212938802 creator A5058955044 @default.
- W3212938802 creator A5064710443 @default.
- W3212938802 creator A5075268966 @default.
- W3212938802 creator A5088809466 @default.
- W3212938802 date "2022-05-01" @default.
- W3212938802 modified "2023-09-26" @default.
- W3212938802 title "Redefinition to bilayer osmotic pump tablets as subterranean river system within mini-earth via three-dimensional structure mechanism" @default.
- W3212938802 cites W1492694960 @default.
- W3212938802 cites W1965900222 @default.
- W3212938802 cites W1969466059 @default.
- W3212938802 cites W1971292300 @default.
- W3212938802 cites W1980397379 @default.
- W3212938802 cites W1986246264 @default.
- W3212938802 cites W1997361375 @default.
- W3212938802 cites W1997615096 @default.
- W3212938802 cites W2000393867 @default.
- W3212938802 cites W2004104883 @default.
- W3212938802 cites W2006023325 @default.
- W3212938802 cites W2028316425 @default.
- W3212938802 cites W2031104076 @default.
- W3212938802 cites W2042673034 @default.
- W3212938802 cites W2043170261 @default.
- W3212938802 cites W2056466604 @default.
- W3212938802 cites W2062374144 @default.
- W3212938802 cites W2062810479 @default.
- W3212938802 cites W2074849801 @default.
- W3212938802 cites W2080712021 @default.
- W3212938802 cites W2081853753 @default.
- W3212938802 cites W2091098807 @default.
- W3212938802 cites W2107862625 @default.
- W3212938802 cites W2137126622 @default.
- W3212938802 cites W2137257460 @default.
- W3212938802 cites W2218084019 @default.
- W3212938802 cites W2280236280 @default.
- W3212938802 cites W2512957460 @default.
- W3212938802 cites W2594867839 @default.
- W3212938802 cites W2612115061 @default.
- W3212938802 cites W2780094800 @default.
- W3212938802 cites W2786527800 @default.
- W3212938802 cites W2793835975 @default.
- W3212938802 cites W3005137976 @default.
- W3212938802 cites W3017288398 @default.
- W3212938802 doi "https://doi.org/10.1016/j.apsb.2021.11.008" @default.
- W3212938802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35646529" @default.
- W3212938802 hasPublicationYear "2022" @default.
- W3212938802 type Work @default.
- W3212938802 sameAs 3212938802 @default.
- W3212938802 citedByCount "1" @default.
- W3212938802 countsByYear W32129388022023 @default.
- W3212938802 crossrefType "journal-article" @default.
- W3212938802 hasAuthorship W3212938802A5000118586 @default.
- W3212938802 hasAuthorship W3212938802A5001629550 @default.
- W3212938802 hasAuthorship W3212938802A5003581530 @default.
- W3212938802 hasAuthorship W3212938802A5014815673 @default.
- W3212938802 hasAuthorship W3212938802A5026252895 @default.
- W3212938802 hasAuthorship W3212938802A5026614129 @default.
- W3212938802 hasAuthorship W3212938802A5027835055 @default.
- W3212938802 hasAuthorship W3212938802A5038430937 @default.
- W3212938802 hasAuthorship W3212938802A5039667666 @default.
- W3212938802 hasAuthorship W3212938802A5045979088 @default.
- W3212938802 hasAuthorship W3212938802A5058955044 @default.
- W3212938802 hasAuthorship W3212938802A5064710443 @default.
- W3212938802 hasAuthorship W3212938802A5075268966 @default.
- W3212938802 hasAuthorship W3212938802A5088809466 @default.
- W3212938802 hasBestOaLocation W32129388021 @default.
- W3212938802 hasConcept C12554922 @default.
- W3212938802 hasConcept C127413603 @default.
- W3212938802 hasConcept C14029885 @default.
- W3212938802 hasConcept C171250308 @default.
- W3212938802 hasConcept C185592680 @default.
- W3212938802 hasConcept C192157962 @default.
- W3212938802 hasConcept C192562407 @default.
- W3212938802 hasConcept C2779820397 @default.
- W3212938802 hasConcept C2781430271 @default.
- W3212938802 hasConcept C2781448156 @default.
- W3212938802 hasConcept C39944091 @default.
- W3212938802 hasConcept C41625074 @default.
- W3212938802 hasConcept C42360764 @default.
- W3212938802 hasConcept C55493867 @default.
- W3212938802 hasConcept C86803240 @default.
- W3212938802 hasConcept C88380143 @default.
- W3212938802 hasConceptScore W3212938802C12554922 @default.
- W3212938802 hasConceptScore W3212938802C127413603 @default.
- W3212938802 hasConceptScore W3212938802C14029885 @default.
- W3212938802 hasConceptScore W3212938802C171250308 @default.
- W3212938802 hasConceptScore W3212938802C185592680 @default.